GEF2_SCHPO - dbPTM
GEF2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GEF2_SCHPO
UniProt AC Q09733
Protein Name Rho guanine nucleotide exchange factor gef2
Gene Name gef2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1101
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Septum.
Protein Description Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation..
Protein Sequence MDVGTMGSRAELLAISIQFGGLWVFRDLLQMNPLFEQDHVFCTFNHPNMGLVLISFAKVDGHILAAYALSKLGPDTFSICYPFSSKLDAFAQTLDLEWQIASMHKEAAACVYEFLCVESVCLHTGENWRESVIEPEYASYIFDTINVFQSSSLTRELYSLGEPNGVREFVVDAIFDIKVDNSWWEDPSNSYWKTVIGSREMFEDSRKKTSSPSPSFASSKDAGTIPAIQKKKSLLIEMMETESTYVERLRHLVNDYALPLRDLAKSSKKLLGLYELNTLFPPCLNKLIQLNSAFLDEFEAIMSDLNFEDIDEKKFEEIDLRLACCFESHFFAFSQHYPRYLEQSNDFGNVLKMASKIPKFVEFHDQVKLNANMNVGLSQLIMEPVQRIPRYSLFLDQIILLTQEGECQHTYVRSVEIIKNIAEMPTVDAEERSRIFAGLQHIIPDLAPNMISNSRNFIDCIDVTREFLKNGQLHLIPYTLILFNDRICLVQRRSKSSIASTILDLRKQNPRNSYSKEKRAQYIGSNMNEAVELTRSMVEENTIFLISKYASSPSFFNEYPILKFRCDFENVRTMDRFYQSFQKALSMNKSQPSCLSFSKLNDFVVFFNNYSRFEYEKESKRSDIVCICTNDANVDKHKFLQDGNIVITFFQQDEDFHLSFDSWLGVSLPTEAVIAKEDLREACLNYLINIKRLLLCPFSNRNFSSLDLYSNLIQHLLSANSSPRKSRLSFGGRPGSPSKISLSLNRFYNQGGLSKSCATLPSQMYNLDHNNISQKSLKFNTHNTSKASAEKTVEHLEAFKGGFKYHTDLKNLLYPLSEKEKIEGDELYDNILKETFNEELLSHYPPNIIYATFQKYLSSFINRKFGVLLSSSFIQQLNTVENLNLSFNSTDAVYHLKKILQDLPESSLKILENIFSIASDLLLRLPLKDQCDFVTKQLAIALAPSMFGSNAVELVYYLAYHSDRIFGTVEELPTPVSPANSNNDKQLDESKFQAIAMKEMPERHPKEILPGQIEREAYEDLRRKYHLTLARLAQMTRLNEDSKKSIPLLYDRFNHDLKLIKQSVQASLIRKQCELDTAKWTLEEYESKLNAKEGCQTNIFI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
209PhosphorylationFEDSRKKTSSPSPSF
HHCCCCCCCCCCCCH		37.1625720772
210PhosphorylationEDSRKKTSSPSPSFA
HCCCCCCCCCCCCHH		49.4825720772
211PhosphorylationDSRKKTSSPSPSFAS
CCCCCCCCCCCCHHC		34.3328889911
213PhosphorylationRKKTSSPSPSFASSK
CCCCCCCCCCHHCCC		34.8124763107
215PhosphorylationKTSSPSPSFASSKDA
CCCCCCCCHHCCCCC		37.4721712547
218PhosphorylationSPSPSFASSKDAGTI
CCCCCHHCCCCCCCC		35.5921712547
219PhosphorylationPSPSFASSKDAGTIP
CCCCHHCCCCCCCCC		31.0025720772
224PhosphorylationASSKDAGTIPAIQKK
HCCCCCCCCCHHHHH		26.0525720772
721PhosphorylationQHLLSANSSPRKSRL
HHHHHCCCCCCCCCC		41.2429996109
722PhosphorylationHLLSANSSPRKSRLS
HHHHCCCCCCCCCCC		28.6529996109
726PhosphorylationANSSPRKSRLSFGGR
CCCCCCCCCCCCCCC		39.4721712547
729PhosphorylationSPRKSRLSFGGRPGS
CCCCCCCCCCCCCCC		22.2724763107
736PhosphorylationSFGGRPGSPSKISLS
CCCCCCCCCCCEEEE		28.7828889911
738PhosphorylationGGRPGSPSKISLSLN
CCCCCCCCCEEEEEC		44.3029996109
741PhosphorylationPGSPSKISLSLNRFY
CCCCCCEEEEECCHH		18.6825720772
743PhosphorylationSPSKISLSLNRFYNQ
CCCCEEEEECCHHHC		19.4625720772
754PhosphorylationFYNQGGLSKSCATLP
HHHCCCCCHHHCCCC		26.2927738172
756PhosphorylationNQGGLSKSCATLPSQ
HCCCCCHHHCCCCHH		12.9521712547
762PhosphorylationKSCATLPSQMYNLDH
HHHCCCCHHHCCCCC		30.6021712547
765PhosphorylationATLPSQMYNLDHNNI
CCCCHHHCCCCCCCC		12.6329996109
773PhosphorylationNLDHNNISQKSLKFN
CCCCCCCCHHHHEEC		33.4121712547
977PhosphorylationEELPTPVSPANSNND
HHCCCCCCCCCCCCC		21.3528889911
981PhosphorylationTPVSPANSNNDKQLD
CCCCCCCCCCCHHCC		38.8329996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GEF2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GEF2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GEF2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PLO1_SCHPOplo1genetic
22298427
MID1_SCHPOmid1physical
22298427
CDR2_SCHPOcdr2genetic
22298427
MID1_SCHPOmid1genetic
22298427
MID1_SCHPOmid1physical
23149940
BLT1_SCHPOblt1physical
23349808
YDEA_SCHPOnod1physical
23349808
YDEA_SCHPOnod1physical
23966468
CDC15_SCHPOcdc15genetic
23966468
GEF3_SCHPOgef3genetic
24947517
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GEF2_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-736 AND SER-977, ANDMASS SPECTROMETRY.

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