| UniProt ID | GDNF_HUMAN | |
|---|---|---|
| UniProt AC | P39905 | |
| Protein Name | Glial cell line-derived neurotrophic factor | |
| Gene Name | GDNF | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 211 | |
| Subcellular Localization | Secreted . | |
| Protein Description | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.. | |
| Protein Sequence | MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 126 | N-linked_Glycosylation | VLTAIHLNVTDLGLG EEEEEECCCCCCCCC | 22.08 | 19478429 | |
| 146 | Phosphorylation | ELIFRYCSGSCDAAE HHHHHHHHCCCCCHH | 25.47 | - | |
| 148 | Phosphorylation | IFRYCSGSCDAAETT HHHHHHCCCCCHHHH | 7.79 | - | |
| 154 | Phosphorylation | GSCDAAETTYDKILK CCCCCHHHHHHHHHH | 26.40 | - | |
| 155 | Phosphorylation | SCDAAETTYDKILKN CCCCHHHHHHHHHHH | 22.64 | - | |
| 156 | Phosphorylation | CDAAETTYDKILKNL CCCHHHHHHHHHHHH | 23.74 | - | |
| 162 | N-linked_Glycosylation | TYDKILKNLSRNRRL HHHHHHHHHHHCCCC | 39.54 | UniProtKB CARBOHYD | |
| 164 | Phosphorylation | DKILKNLSRNRRLVS HHHHHHHHHCCCCCC | 36.58 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GDNF_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GDNF_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GDNF_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ATRAP_HUMAN | AGTRAP | physical | 25416956 | |
| MAEA_HUMAN | MAEA | physical | 26186194 | |
| MKLN1_HUMAN | MKLN1 | physical | 26186194 | |
| RMD5A_HUMAN | RMND5A | physical | 26186194 | |
| RANB9_HUMAN | RANBP9 | physical | 26186194 | |
| RBP10_HUMAN | RANBP10 | physical | 26186194 | |
| ARMC8_HUMAN | ARMC8 | physical | 26186194 | |
| S10AA_HUMAN | S100A10 | physical | 26186194 | |
| GID4_HUMAN | GID4 | physical | 26186194 | |
| YPEL5_HUMAN | YPEL5 | physical | 26186194 | |
| GID4_HUMAN | GID4 | physical | 28514442 | |
| ARMC8_HUMAN | ARMC8 | physical | 28514442 | |
| MAEA_HUMAN | MAEA | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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