GCSH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCSH_HUMAN
• UniProt AC: P23434
• Protein Name: Glycine cleavage system H protein, mitochondrial {ECO:0000303|PubMed:1671321}
• Gene Name: GCSH {ECO:0000312|HGNC:HGNC:4208}
• Organism: Homo sapiens (Human).
• Sequence Length: 173
• Subcellular Localization: Mitochondrion .
• Protein Description: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST)..
• Protein Sequence: MALRVVRSVRALLCTLRAVPSPAAPCPPRPWQLGVGAVRTLRTGPALLSVRKFTEKHEWVTTENGIGTVGISNFAQEALGDVVYCSLPEVGTKLNKQDEFGALESVKAASELYSPLSGEVTEINEALAENPGLVNKSCYEDGWLIKMTLSNPSELDELMSEEAYEKYIKSIEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	GAVRTLRTGPALLSV CHHHCCCCCCCEEEE	51.10	-
49	Phosphorylation	RTGPALLSVRKFTEK CCCCCEEEEEECCCC	22.26	-
61	Phosphorylation	TEKHEWVTTENGIGT CCCCCEEECCCCCCE	29.48	24275569
86	Phosphorylation	LGDVVYCSLPEVGTK HCCCEEECCCCCCCC	29.31	24275569
107	N6-lipoyllysine	FGALESVKAASELYS CCHHHHHHHHHHHHC	47.73	-
107	Lipoylation	FGALESVKAASELYS CCHHHHHHHHHHHHC	47.73	-
107	Lipoylation	FGALESVKAASELYS CCHHHHHHHHHHHHC	47.73	1671321
117	Phosphorylation	SELYSPLSGEVTEIN HHHHCCCCCCCCHHH	35.97	24275569
138	Glutathionylation	PGLVNKSCYEDGWLI CCCCCHHHHCCCEEE	4.62	22555962
139	Phosphorylation	GLVNKSCYEDGWLIK CCCCHHHHCCCEEEE	24.93	28152594
148	Phosphorylation	DGWLIKMTLSNPSEL CCEEEEEECCCHHHH	23.25	21406692
150	Phosphorylation	WLIKMTLSNPSELDE EEEEEECCCHHHHHH	37.21	21406692
153	Phosphorylation	KMTLSNPSELDELMS EEECCCHHHHHHHHC	55.85	21406692
160	Phosphorylation	SELDELMSEEAYEKY HHHHHHHCHHHHHHH	44.93	29507054
164	Phosphorylation	ELMSEEAYEKYIKSI HHHCHHHHHHHHHHH	19.08	21406692
166	Succinylation	MSEEAYEKYIKSIEE HCHHHHHHHHHHHCC	39.33	23954790
166	Acetylation	MSEEAYEKYIKSIEE HCHHHHHHHHHHHCC	39.33	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCSH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCSH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCSH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NMI_HUMAN	NMI	physical	16189514
ING5_HUMAN	ING5	physical	16169070
ZBT16_HUMAN	ZBTB16	physical	16169070
NMI_HUMAN	NMI	physical	25416956
SFI1_HUMAN	SFI1	physical	25416956
PSB5_HUMAN	PSMB5	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 605899: Non-ketotic hyperglycinemia (NKH)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00145: Glycine