FGF7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FGF7_HUMAN
• UniProt AC: P21781
• Protein Name: Fibroblast growth factor 7
• Gene Name: FGF7
• Organism: Homo sapiens (Human).
• Sequence Length: 194
• Subcellular Localization: Secreted.
• Protein Description: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation..
• Protein Sequence: MHKWILTWILPTLLYRSCFHIICLVGTISLACNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MHKWILTWILPTLL -CCHHHHHHHHHHHH	11.00	25072903
12	Phosphorylation	ILTWILPTLLYRSCF HHHHHHHHHHHHHHH	26.42	25072903
15	Phosphorylation	WILPTLLYRSCFHII HHHHHHHHHHHHHHH	12.00	23663014
45	N-linked_Glycosylation	EQMATNVNCSSPERH HHHHHCCCCCCCCCC	23.25	UniProtKB CARBOHYD
55	Phosphorylation	SPERHTRSYDYMEGG CCCCCCCCCCCCCCC	24.42	-
56	Phosphorylation	PERHTRSYDYMEGGD CCCCCCCCCCCCCCC	14.06	-
58	Phosphorylation	RHTRSYDYMEGGDIR CCCCCCCCCCCCCEE	6.71	-
115	Phosphorylation	VAIKGVESEFYLAMN EEEECCCEEEEEEEC	30.51	28787133
118	Phosphorylation	KGVESEFYLAMNKEG ECCCEEEEEEECCCC	6.90	28787133
181	Acetylation	VRGKKTKKEQKTAHF CCCCCCHHHHHCCCC	71.28	30588773

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FGF7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FGF7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FGF7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PGBM_HUMAN	HSPG2	physical	10702276
DESI1_HUMAN	DESI1	physical	21988832
UBQL1_HUMAN	UBQLN1	physical	21988832
FGFR2_HUMAN	FGFR2	physical	11714710

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.