FCA_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FCA_ARATH
• UniProt AC: O04425
• Protein Name: Flowering time control protein FCA
• Gene Name: FCA
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 747
• Subcellular Localization: Nucleus .
• Protein Description: Plays a major role in the promotion of the transition of the vegetative meristem to reproductive development. Plays a role in the regulation of flowering time in the autonomous flowering pathway by decreasing FLOWERING LOCUS C mRNA levels. Required for RNA-mediated chromatin silencing of a range of loci in the genome. Cotranscriptionally recognizes aberrant RNA and marks it for silencing. Controls alternative cleavage and polyadenylation on pre-mRNAs and antisense RNAs. Acts redundantly with FPA to prevent the expression of distally polyadenylated antisense RNAs at the FLC locus..
• Protein Sequence: MNGPPDRVDFKPMGPHHGGSFRPMGFAYDDGFRPMGPNGGVGGEGTRSIVGARYNYPAKYPPSESPDRRRFIGKAMESDYSVRPTTPPVQQPLSGQKRGYPISDHGSFTGTDVSDRSSTVKLFVGSVPRTATEEEIRPYFEQHGNVLEVALIKDKRTGQQQGCCFVKYATSKDADRAIRALHNQITLPGGTGPVQVRYADGERERIGTLEFKLFVGSLNKQATEKEVEEIFLQFGHVEDVYLMRDEYRQSRGCGFVKYSSKETAMAAIDGLNGTYTMRGCNQPLIVRFAEPKRPKPGESREMAPPVGLGSGPRFQASGPRPTSNFGDSSGDVSHTNPWRPATSRNVGPPSNTGIRGAGSDFSPKPGQATLPSNQGGPLGGYGVPPLNPLPVPGVSSSATLQQQNRAAGQHITPLKKPLHSPQGLPLPLRPQTNFPGAQAPLQNPYAYSSQLPTSQLPPQQNISRATAPQTPLNINLRPTTVSSATVQFPPRSQQQPLQKMQHPPSELAQLLSQQTQSLQATFQSSQQAISQLQQQVQSMQQPNQNLPLSQNGRAGKQQWAGSAIPRVASTTGSTPVSYVQTAAPAVSQSVGSVKCTWTEHTSPDGFKYYYNGLTGESKWEKPEEMIVFEREQQKQQQHQEKPTIQQSQTQLQPLQQQPQQVQQQYQGQQLQQPFYSSLYPTPGASHNTQYPSLPVGQNSQFPMSGIGQNAQDYARTHIPVGAASMNDISRTQQSRQSPQELMWKNKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	YPAKYPPSESPDRRR CCCCCCCCCCCCHHH	46.32	25561503
65	Phosphorylation	AKYPPSESPDRRRFI CCCCCCCCCCHHHHH	36.12	25561503
737	Phosphorylation	RTQQSRQSPQELMWK HHHHHHCCHHHHHHC	27.69	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FCA_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FCA_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FCA_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASHH2_ARATH	EFS	genetic	10518493
FY_ARATH	FY	physical	12809608
FY_ARATH	FY	physical	18854333
FY_ARATH	FY	physical	16033802
SWI3A_ARATH	SWI3A	physical	16055636
PIF4_ARATH	PIF4	physical	25400039
ABI5_ARATH	ABI5	physical	25266977

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.