F219B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F219B_HUMAN
• UniProt AC: Q5XKK7
• Protein Name: Protein FAM219B
• Gene Name: FAM219B
• Organism: Homo sapiens (Human).
• Sequence Length: 198
• Protein Sequence: MATAEPSGRALRLSTPGPRPSGARDRAPGAAGPPSGQIGNRALRLGERTPAAVEKRGPYMVTRAPSIQAKLQKHRDLAKAVLRRKGMLGASPNRPDSSGKRSVKFNKGYTALSQSPDENLVSLDSDSDGELGSRYSSGYSSAEQVNQDVSRQLLQDGYHLDEIPDDEDLDLIPPKPMASSTCSCCWCCLGDSSSCTLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	SGRALRLSTPGPRPS CCCCEECCCCCCCCC	26.56	28985074
15	Phosphorylation	GRALRLSTPGPRPSG CCCEECCCCCCCCCC	36.54	28985074
21	Phosphorylation	STPGPRPSGARDRAP CCCCCCCCCCCCCCC	46.49	28985074
35	Phosphorylation	PGAAGPPSGQIGNRA CCCCCCCCCCCCHHH	46.60	28674419
55	Ubiquitination	RTPAAVEKRGPYMVT CCCHHHHHHCCCEEE	56.93	-
59	Phosphorylation	AVEKRGPYMVTRAPS HHHHHCCCEEECCHH	13.67	25884760
62	Phosphorylation	KRGPYMVTRAPSIQA HHCCCEEECCHHHHH	12.46	23882029
66	Phosphorylation	YMVTRAPSIQAKLQK CEEECCHHHHHHHHH	26.75	26074081
91	Phosphorylation	RKGMLGASPNRPDSS HCCCCCCCCCCCCCC	22.40	29255136
97	Phosphorylation	ASPNRPDSSGKRSVK CCCCCCCCCCCCEEE	43.61	29396449
98	Phosphorylation	SPNRPDSSGKRSVKF CCCCCCCCCCCEEEE	56.57	27251275
109	Phosphorylation	SVKFNKGYTALSQSP EEEECCCCEECCCCC	7.17	22115753
110	Phosphorylation	VKFNKGYTALSQSPD EEECCCCEECCCCCC	29.77	22115753
113	Phosphorylation	NKGYTALSQSPDENL CCCCEECCCCCCCCC	26.58	29978859
115	Phosphorylation	GYTALSQSPDENLVS CCEECCCCCCCCCEE	30.83	25850435
122	Phosphorylation	SPDENLVSLDSDSDG CCCCCCEECCCCCCC	29.62	22115753
125	Phosphorylation	ENLVSLDSDSDGELG CCCEECCCCCCCCCC	44.28	25159151
127	Phosphorylation	LVSLDSDSDGELGSR CEECCCCCCCCCCCC	52.01	25159151
133	Phosphorylation	DSDGELGSRYSSGYS CCCCCCCCCCCCCCC	40.44	30108239
135	Phosphorylation	DGELGSRYSSGYSSA CCCCCCCCCCCCCCH	14.64	28796482
136	Phosphorylation	GELGSRYSSGYSSAE CCCCCCCCCCCCCHH	19.04	28796482
137	Phosphorylation	ELGSRYSSGYSSAEQ CCCCCCCCCCCCHHH	32.58	28796482
139	Phosphorylation	GSRYSSGYSSAEQVN CCCCCCCCCCHHHHC	11.03	28796482
140	Phosphorylation	SRYSSGYSSAEQVNQ CCCCCCCCCHHHHCH	26.97	28796482
141	Phosphorylation	RYSSGYSSAEQVNQD CCCCCCCCHHHHCHH	27.60	28796482
181	Phosphorylation	PKPMASSTCSCCWCC CCCCCCCCCCEEEEE	13.12	30576142
196	Phosphorylation	LGDSSSCTLQ----- CCCCCCCCCC-----	30.09	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F219B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F219B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F219B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JIP4_HUMAN	SPAG9	physical	26186194
ELP1_HUMAN	IKBKAP	physical	26186194
DPH2_HUMAN	DPH2	physical	26186194
ELP2_HUMAN	ELP2	physical	26186194
MTCH2_HUMAN	MTCH2	physical	26186194
MTU1_HUMAN	TRMU	physical	26186194
ELP3_HUMAN	ELP3	physical	26186194
MTU1_HUMAN	TRMU	physical	28514442
DPH2_HUMAN	DPH2	physical	28514442
ELP3_HUMAN	ELP3	physical	28514442
JIP4_HUMAN	SPAG9	physical	28514442
MTCH2_HUMAN	MTCH2	physical	28514442
ELP2_HUMAN	ELP2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125 AND SER-127, ANDMASS SPECTROMETRY.
PubMed: 18669648