dbPTM

ETS2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ETS2_MOUSE
UniProt AC	P15037
Protein Name	Protein C-ets-2
Gene Name	Ets2
Organism	Mus musculus (Mouse).
Sequence Length	468
Subcellular Localization	Nucleus.
Protein Description	Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity)..
Protein Sequence	MNDFGIKNMDQVAPVANSFRGTLKRQPAFDTFDGSLFAVLPSLSEDQTLQEVPTGLDSVSHDSASCELPLLTPCSKAVMSQALKATFSGFQKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLHQFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEENSHLNAVPHWINSNTLGFSMEQAPYGMQAPNYPKDNLLDSMCPPSATPAALGSELQMLPKSRLNTVNVNYCSISQDFPSSNVNLLNNNSGKPKDHDSPENGGDSFESSDSLLRSWNSQSSLLDVQRVPSFESFEEDCSQSLCLSKLTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	SCELPLLTPCSKAVM CCCCCCCCCCCHHHH	29.90	14612405
220	Phosphorylation	PKDNLLDSMCPPSAT CCCCCCHHCCCCCCC	23.43	-
225	Phosphorylation	LDSMCPPSATPAALG CHHCCCCCCCHHHHH	29.89	-
284	Phosphorylation	SPENGGDSFESSDSL CCCCCCCCCCCHHHH	33.90	27742792
294	Phosphorylation	SSDSLLRSWNSQSSL CHHHHHHHCCCCCCC	30.49	23984901
297	Phosphorylation	SLLRSWNSQSSLLDV HHHHHCCCCCCCCCC	25.77	28725479
299	Phosphorylation	LRSWNSQSSLLDVQR HHHCCCCCCCCCCCC	23.83	21743459
300	Phosphorylation	RSWNSQSSLLDVQRV HHCCCCCCCCCCCCC	25.89	29233185
309	Phosphorylation	LDVQRVPSFESFEED CCCCCCCCCHHHHHH	38.50	22817900
312	Phosphorylation	QRVPSFESFEEDCSQ CCCCCCHHHHHHHHH	35.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
72	T	Phosphorylation	Kinase	MAPK1	P63085	GPS
72	T	Phosphorylation	Kinase	MAPK3	Q63844	GPS
72	T	Phosphorylation	Kinase	MAPK9	Q9WTU6	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
220	S	Phosphorylation	-
Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.
225	S	Phosphorylation	-
Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ETS2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CERS2_MOUSE	Cers2	physical	20211142
SMCA4_MOUSE	Smarca4	physical	12637547
SMCE1_MOUSE	Smarce1	physical	12637547
SNF5_MOUSE	Smarcb1	physical	12637547
PRDM1_MOUSE	Prdm1	physical	17977828

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ETS2_MOUSE

Related Literatures of Post-Translational Modification