ERCC2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERCC2_ARATH
• UniProt AC: Q8W4M7
• Protein Name: General transcription and DNA repair factor IIH helicase subunit XPD
• Gene Name: XPD {ECO:0000303|PubMed:16623910}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 758
• Subcellular Localization: Nucleus .
• Protein Description: ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD acts by forming a bridge between CAK and the core-TFIIH complex (By similarity). Essential during plant growth. [PubMed: 12857822 May negatively regulate a common response program mediated by UV damage and heat stress, that leads to tissue death and reduced chloroplast function]
• Protein Sequence: MIFKIEDVTVYFPYDNIYPEQYEYMVELKRALDAKGHCLLEMPTGTGKTIALLSLITSYRLSRPDSPIKLVYCTRTVHEMEKTLGELKLLHDYQVRHLGTQAKILALGLSSRKNLCVNTKVLAAENRDSVDAACRKRTASWVRALSTENPNVELCDFFENYEKAAENALLPPGVYTLEDLRAFGKNRGWCPYFLARHMIQFANVIVYSYQYLLDPKVAGFISKELQKESVVVFDEAHNIDNVCIEALSVSVRRVTLEGANRNLNKIRQEIDRFKATDAGRLRAEYNRLVEGLALRGDLSGGDQWLANPALPHDILKEAVPGNIRRAEHFVHVLRRLLQYLGVRLDTENVEKESPVSFVSSLNSQAGIEQKTLKFCYDRLQSLMLTLEITDTDEFLPIQTVCDFATLVGTYARGFSIIIEPYDERMPHIPDPILQLSCHDASLAIKPVFDRFQSVVITSGTLSPIDLYPRLLNFTPVVSRSFKMSMTRDCICPMVLTRGSDQLPVSTKFDMRSDPGVVRNYGKLLVEMVSIVPDGVVCFFVSYSYMDGIIATWNETGILKEIMQQKLVFIETQDVVETTLALDNYRRACDCGRGAVFFSVARGKVAEGIDFDRHYGRLVVMYGVPFQYTLSKILRARLEYLHDTFQIKEGDFLTFDALRQAAQCVGRVIRSKADYGMMIFADKRYSRHDKRSKLPGWILSHLRDAHLNLSTDMAIHIAREFLRKMAQPYDKAGTMGRKTLLTQEDLEKMAETGVQDMAY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	Phosphorylation	YQVRHLGTQAKILAL HHHHHHHHHHHHHHH	31.54	25368622
248	Phosphorylation	NVCIEALSVSVRRVT HHHHHHHCEEEEEEE	21.28	28011693
250	Phosphorylation	CIEALSVSVRRVTLE HHHHHCEEEEEEECC	13.41	28011693
353	Phosphorylation	TENVEKESPVSFVSS CCCCCCCCCCCHHHH	41.49	19880383
356	Phosphorylation	VEKESPVSFVSSLNS CCCCCCCCHHHHHHC	24.26	23111157
363	Phosphorylation	SFVSSLNSQAGIEQK CHHHHHHCCCCCCHH	27.05	23111157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERCC2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERCC2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERCC2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFB1A_ARATH	AT1G55750	physical	20706207
CCH11_ARATH	CYCH;1	physical	20706207
PSMD6_ARATH	AT4G24820	physical	20706207

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.