TFB1A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFB1A_ARATH
• UniProt AC: Q3ECP0
• Protein Name: General transcription and DNA repair factor IIH subunit TFB1-1
• Gene Name: TFB1-1 {ECO:0000305}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 591
• Subcellular Localization: Nucleus .
• Protein Description: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription..
• Protein Sequence: MAGGQIEKLVKYKSTVKDPGTPGFLRIREGMLLFVPNDPKSDSKLKVLTQNIKSQKYTKEGSNKPPWLNLTNKQAKSHIFEFENYPDMHACRDFITKALAKCELEPNKSVVSTSSEQLSIKELELRFKLLRENSELQRLHKQFVESKVLTEDEFWATRKKLLGKDSIRKSKQQLGLKSMMVSGIKPSTDGRTNRVTFNLTPEIIFQIFAEKPAVRQAFINYVPSKMTEKDFWTKYFRAEYLYSTKNTAVAAAEAAEDEELAVFLKPDEILARETRHKIRRVDPTLDMEADQGDDYTHLMDHGIQRDGTMDVVEPQNDQFKRSLLQDLNRHAAVVLEGRSIDVESEDTRIVAEALTRVKQVSKADGETTKDANQERLERMSRVAGMEDLQAPQNFPLAPLSIKDPRDYFESQQGNVLNVPRGAKGLKRNVHEAYGLLKESILEIRATGLSDPLIKPEVSFEVFSSLTRTIATAKNINGKNPRESFLDRLPKSTKDEVLHHWTSIQELLKHFWSSYPITTTYLHTKVGKLKDAMSNTYSKLEAMKESVQSDLRHQVSLLVRPMQQALDAAFHHYEVDLQRRTAKSGERPNGYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	QKYTKEGSNKPPWLN CCCCCCCCCCCCCCC	42.65	27545962
134	Phosphorylation	FKLLRENSELQRLHK HHHHHCCHHHHHHHH	34.62	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TFB1A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFB1A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFB1A_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of TFB1A_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.