EF2KT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EF2KT_HUMAN
• UniProt AC: Q96G04
• Protein Name: Protein-lysine N-methyltransferase EEF2KMT {ECO:0000305}
• Gene Name: EEF2KMT {ECO:0000312|HGNC:HGNC:32221}
• Organism: Homo sapiens (Human).
• Sequence Length: 330
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'..
• Protein Sequence: MAPEENAGTELLLQSFERRFLAARTLRSFPWQSLEAKLRDSSDSELLRDILHKTVKHPVCVKHPPSVKYARCFLSELIKKHEAVHTEPLDELYEALAETLMAKESTQGHRSYLLPSGGSVTLSESTAIISYGTTGLVTWDAALYLAEWAIENPAVFTNRTVLELGSGAGLTGLAICKMCRPRAYIFSDCHSRVLEQLRGNVLLNGLSLEADITAKLDSPRVTVAQLDWDVATVHQLSAFQPDVVIAADVLYCPEAIMSLVGVLRRLAACREHQRAPEVYVAFTVRNPETCQLFTTELGRAGIRWEVEPRHEQKLFPYEEHLEMAMLNLTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MAPEENAG -------CCCCCCHH		22814378
9	Phosphorylation	APEENAGTELLLQSF CCCCCHHHHHHHHHH		24043423
15	Phosphorylation	GTELLLQSFERRFLA HHHHHHHHHHHHHHH		24043423
33	Phosphorylation	LRSFPWQSLEAKLRD HHHCCHHHHHHHHCC		24719451
37 (in isoform 2)	Ubiquitination	-		21906983
37 (in isoform 1)	Ubiquitination	-		21906983
37	Ubiquitination	PWQSLEAKLRDSSDS CHHHHHHHHCCCCCH		-
53	Ubiquitination	LLRDILHKTVKHPVC HHHHHHHHHCCCCCH		-
54	O-linked_Glycosylation	LRDILHKTVKHPVCV HHHHHHHHCCCCCHH		31492838
56	Ubiquitination	DILHKTVKHPVCVKH HHHHHHCCCCCHHCC		-
62	Ubiquitination	VKHPVCVKHPPSVKY CCCCCHHCCCCCHHH		-
69	Phosphorylation	KHPPSVKYARCFLSE CCCCCHHHHHHHHHH		22817901
105	Phosphorylation	ETLMAKESTQGHRSY HHHHHHCCCCCCCCE		-
106	Phosphorylation	TLMAKESTQGHRSYL HHHHHCCCCCCCCEE		-
134	Phosphorylation	AIISYGTTGLVTWDA EEEEECCCCCCHHHH		25332170
177	Ubiquitination	LTGLAICKMCRPRAY HHHHHHHHHCCCCEE		-
184	Phosphorylation	KMCRPRAYIFSDCHS HHCCCCEEEEHHHHH		-
191	Phosphorylation	YIFSDCHSRVLEQLR EEEHHHHHHHHHHHH		-
222	Phosphorylation	KLDSPRVTVAQLDWD ECCCCCEEEEECCCC		24043423
232	Phosphorylation	QLDWDVATVHQLSAF ECCCCHHHHHHHHCC		24043423
237	Phosphorylation	VATVHQLSAFQPDVV HHHHHHHHCCCCCEE		24043423
251	Phosphorylation	VIAADVLYCPEAIMS EEEECEECCHHHHHH		24043423
258	Phosphorylation	YCPEAIMSLVGVLRR CCHHHHHHHHHHHHH		24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EF2KT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EF2KT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EF2KT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF2_HUMAN	EEF2	physical	23349634
F86B2_HUMAN	FAM86B2	physical	23349634
FA86C_HUMAN	FAM86C1	physical	23349634
GRP78_HUMAN	HSPA5	physical	23349634
EF2_HUMAN	EEF2	physical	25231979
EF2_YEAST	EFT2	physical	25231979
EF2_HUMAN	EEF2	physical	26186194
BCAT2_HUMAN	BCAT2	physical	26186194
ECI2_HUMAN	ECI2	physical	26186194
GTPB1_HUMAN	GTPBP1	physical	26186194
UBP15_HUMAN	USP15	physical	26186194
GALC_HUMAN	GALC	physical	26186194
BCAT2_HUMAN	BCAT2	physical	28514442
GALC_HUMAN	GALC	physical	28514442
EF2_HUMAN	EEF2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.