E4F1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: E4F1_MOUSE
• UniProt AC: Q8CCE9
• Protein Name: Transcription factor E4F1
• Gene Name: E4f1
• Organism: Mus musculus (Mouse).
• Sequence Length: 783
• Subcellular Localization: Nucleus, nucleoplasm . Cytoplasm. A small fraction is detected in the cytoplasm (By similarity). Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis..
• Protein Description: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription..
• Protein Sequence: MEGAMAVRVTAAHTAEARAEAGREAGEGGVAAAAALSSGGFLGLPAPFSEEDEDDVHRCGRCQVEFTALEDFVQHKIQKTCHRAPQEALPTTPAATALLDQEVVPTAAEGGPDEPITVAHIVVEATSLAEDISHAPDLVGSGHIKEVIVAAEAEPGDVEMAEAPGSPNHQELGLLGEGEQAHVKLLVNKEGRYVCMLCHKTFKTGSILKAHMVTHSSRKDHECKLCGASFRTKGSLIRHHRRHTDERPYKCAKCGKSFRESGALTRHLKSLTPCTEKIRFSISKDTAVGKEEVPAGSSASTVGTVTSSVAGDPMETSPVIHLVTDAKGTVIHEVHVQMQELPLGMKALTPESPDSEELPCSSENSRENLLHQAMQNSGIVLERVAGEESALEPAPPSGSSPQCLGDGSPELPLLKVEQIETQVASEAATVPRTHPCPQCSETFPTAATLEAHKRGHIAPRPFTCTQCGKAFPKAYLLKKHQEVHVHERRFRCGDCGKLYKTIAHVRGHRRVHSDERPFPCPQCGKRYKTKNAQQVHFRTHLEEKPHVCQFCSRGFREKGSLVRHVRHHTGEKPFKCYKCGRGFAEHGTLNRHLRTKGGCLLEVEELLVSEESPSAAATVLAEDPHTVLVEFSSVVADTQEYIIEATADDTETSEATEIIEGTQTEVDSHIMKVVQQIVHQAGAGHQIIVQNVTMDQETALGSEATAADTITIATPESLTEQVAMTLASAISEGTVLTARAGPNSTEQATVTMVSSEDIEILEHGGELVIASPEGQLEVQTVIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	LGLPAPFSEEDEDDV CCCCCCCCCCCCCCC	38.73	-
166	Phosphorylation	EMAEAPGSPNHQELG EEEECCCCCCCHHCC	22.82	25266776
349	Phosphorylation	PLGMKALTPESPDSE CCCCEECCCCCCCCC	29.84	25619855
352	Phosphorylation	MKALTPESPDSEELP CEECCCCCCCCCCCC	34.90	25619855
355	Phosphorylation	LTPESPDSEELPCSS CCCCCCCCCCCCCCC	36.03	25619855
361	Phosphorylation	DSEELPCSSENSREN CCCCCCCCCCCHHHH	38.45	25619855
362	Phosphorylation	SEELPCSSENSRENL CCCCCCCCCCHHHHH	47.73	25619855
397	Phosphorylation	ALEPAPPSGSSPQCL CCCCCCCCCCCCCCC	50.69	21189417
400	Phosphorylation	PAPPSGSSPQCLGDG CCCCCCCCCCCCCCC	23.63	22817900
408	Phosphorylation	PQCLGDGSPELPLLK CCCCCCCCCCCCEEE	21.68	22817900
408 (in isoform 3)	Phosphorylation	-	21.68	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of E4F1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of E4F1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of E4F1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NFE2_MOUSE	Nfe2	physical	20211142
GMEB2_MOUSE	Gmeb2	physical	20211142
AN32A_MOUSE	Anp32a	physical	17557114

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.