AN32A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AN32A_MOUSE
• UniProt AC: O35381
• Protein Name: Acidic leucine-rich nuclear phosphoprotein 32 family member A
• Gene Name: Anp32a
• Organism: Mus musculus (Mouse).
• Sequence Length: 247
• Subcellular Localization: Nucleus . Cytoplasm . Endoplasmic reticulum. Shuttles between nucleus and cytoplasm. Translocates to the cytoplasm during the process of neuritogenesis.
• Protein Description: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression..
• Protein Sequence: MEMDKRIYLELRNRTPSDVKELVLDNCKSIEGKIEGLTDEFEELEFLSTINVGLTSISNLPKLNKLKKLELSENRISGDLEVLAEKCPNLKHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNAYRENVFKLLPQVMYLDGYDRDNKEAPDSDVEGYVEDDDEEDEDEEEYDEYAQLVEDEEEEDEEEEGEEEDVSGEEEEDEEGYNDGEVDDEEDEEEAGEEEGSQKRKREPDDEGEEDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MEMDKRIYLELRNRT CCCCHHHHHHHCCCC	9.73	23023260
15	Phosphorylation	YLELRNRTPSDVKEL HHHHCCCCHHHHHHH	30.60	25521595
17	Phosphorylation	ELRNRTPSDVKELVL HHCCCCHHHHHHHHH	55.19	25521595
20	Ubiquitination	NRTPSDVKELVLDNC CCCHHHHHHHHHHHH	50.77	22790023
27	Glutathionylation	KELVLDNCKSIEGKI HHHHHHHHHHCCCHH	3.50	24333276
28	Ubiquitination	ELVLDNCKSIEGKIE HHHHHHHHHCCCHHC	61.80	-
28	Malonylation	ELVLDNCKSIEGKIE HHHHHHHHHCCCHHC	61.80	26320211
68	Ubiquitination	PKLNKLKKLELSENR CCHHCCCCCCCCCCC	58.59	22790023
72	Phosphorylation	KLKKLELSENRISGD CCCCCCCCCCCCCCC	24.37	22817900
77	Phosphorylation	ELSENRISGDLEVLA CCCCCCCCCCHHHHH	24.02	26824392
86	Ubiquitination	DLEVLAEKCPNLKHL CHHHHHHHCCCCCEE	49.76	22790023
91	Ubiquitination	AEKCPNLKHLNLSGN HHHCCCCCEECCCCC	53.32	22790023
99	Ubiquitination	HLNLSGNKIKDLSTI EECCCCCCCCCHHHC	55.44	-
99	Malonylation	HLNLSGNKIKDLSTI EECCCCCCCCCHHHC	55.44	26320211
101	Ubiquitination	NLSGNKIKDLSTIEP CCCCCCCCCHHHCHH	54.98	-
101	Malonylation	NLSGNKIKDLSTIEP CCCCCCCCCHHHCHH	54.98	26320211
104	Phosphorylation	GNKIKDLSTIEPLKK CCCCCCHHHCHHHHH	37.16	54887289
105	Phosphorylation	NKIKDLSTIEPLKKL CCCCCHHHCHHHHHH	36.34	23984901
117	Phosphorylation	KKLENLKSLDLFNCE HHHHCCCCCCCCCCE	30.22	26643407
137	Ubiquitination	AYRENVFKLLPQVMY HHHHHHHHHHCCCCC	44.85	22790023
158	Phosphorylation	DNKEAPDSDVEGYVE CCCCCCCCCCCCCCC	42.36	61321
202	Phosphorylation	EGEEEDVSGEEEEDE HCCCCCCCCCHHHCC	53.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AN32A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AN32A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AN32A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
E4F1_MOUSE	E4f1	physical	17557114

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.