E2FB_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: E2FB_ARATH
• UniProt AC: Q9FV71
• Protein Name: Transcription factor E2FB
• Gene Name: E2FB
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 469
• Subcellular Localization: Cytoplasm. Nucleus. Interaction with DPA induces an exclusive nuclear localization, but an interaction with DPB has no effect.
• Protein Description: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions..
• Protein Sequence: MSEEVPQQFPSSKRQLHPSLSSMKPPLVAPGEYHRFDAAETRGGGAVADQVVSDAIVIKSTLKRKTDLVNQIVEVNELNTGVLQTPVSGKGGKAKKTSRSAKSNKSGTLASGSNAGSPGNNFAQAGTCRYDSSLGLLTKKFINLIKQAEDGILDLNKAADTLEVQKRRIYDITNVLEGIGLIEKTLKNRIQWKGLDVSKPGETIESIANLQDEVQNLAAEEARLDDQIRESQERLTSLSEDENNKRLLFVTENDIKNLPCFQNKTLIAVKAPHGTTLEVPDPDEAGGYQRRYRIILRSTMGPIDVYLVSQFEESFEDIPQADEPSNVPDEPSNVPDVPSNLPSTSGLPENHDVSMPMKEESTERNMETQEVDDTQRVYSDIESHDFVDGIMKIVPPDLDMGVDYWFRSEVGEVSITDMWPDESGPDWNQMITFDQDHAGPSDNKILEQPQTPSSPTPEESTATRSPTGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
113	Phosphorylation	SGTLASGSNAGSPGN CCCCCCCCCCCCCCC	22.47	25561503
117	Phosphorylation	ASGSNAGSPGNNFAQ CCCCCCCCCCCCCCC	27.50	30291188
130	Phosphorylation	AQAGTCRYDSSLGLL CCCCCCCCCCHHHHH	23.48	23328941
251	Phosphorylation	NKRLLFVTENDIKNL CCEEEEEEHHHHCCC	23.03	19880383
378	Phosphorylation	VDDTQRVYSDIESHD CCCHHHHHHHHHHCC	11.65	23111157
379	Phosphorylation	DDTQRVYSDIESHDF CCHHHHHHHHHHCCC	29.29	23111157
451	Phosphorylation	KILEQPQTPSSPTPE CCCCCCCCCCCCCCC	31.64	23776212
453	Phosphorylation	LEQPQTPSSPTPEES CCCCCCCCCCCCCHH	52.95	23776212
454	Phosphorylation	EQPQTPSSPTPEEST CCCCCCCCCCCCHHC	33.71	30291188
456	Phosphorylation	PQTPSSPTPEESTAT CCCCCCCCCCHHCCC	45.33	23776212
460	Phosphorylation	SSPTPEESTATRSPT CCCCCCHHCCCCCCC	22.98	23776212
461	Phosphorylation	SPTPEESTATRSPTG CCCCCHHCCCCCCCC	35.01	23776212
463	Phosphorylation	TPEESTATRSPTGS- CCCHHCCCCCCCCC-	31.59	23776212
465	Phosphorylation	EESTATRSPTGS--- CHHCCCCCCCCC---	23.58	23776212
467	Phosphorylation	STATRSPTGS----- HCCCCCCCCC-----	51.83	23776212
469	Phosphorylation	ATRSPTGS------- CCCCCCCC-------	39.26	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of E2FB_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of E2FB_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of E2FB_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPA_ARATH	DPA	physical	20407024
DPB_ARATH	DPB	physical	20407024
RBR1_ARATH	RBR1	physical	20706207
PSMD6_ARATH	AT4G24820	physical	20706207
GSXL1_ARATH	AT1G12160	physical	20706207
MDHC1_ARATH	AT1G04410	physical	20706207
DPA_ARATH	DPA	physical	11108847
DPB_ARATH	DPB	physical	11108847

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.