DRB1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRB1_ARATH
• UniProt AC: O04492
• Protein Name: Double-stranded RNA-binding protein 1
• Gene Name: DRB1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 419
• Subcellular Localization: Nucleus . Nucleus speckle . Localizes to nuclear dicing body (also named D body), a nuclear body distributed throughout the nucleoplasm and involved in miRNA processing.
• Protein Description: Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis by assisting DICER-LIKE 1 (DCL1) in the accurate processing from primary miRNAs (pri-miRNAs) to miRNAs in the nucleus. Forms a complex with SERRATE (SE) and DCL1 to promote accurate processing of pri-miRNAs by DCL1. Binds and assist DCL1 for accurate processing of precursor miRNAs (pre-miRNA). Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved with argonaute 1 (AGO1) in the guide strand selection from miRNA duplexes, presumably by directional loading of the miRNA duplex (guide stand and passenger strand) onto the RNA-induced silencing complex (RISC) for passenger strand degradation. Does not participate in sense transgene-induced post-transcriptional gene silencing (S-PTGS). Involved in several plant development aspects and response to hormones through its role in miRNAs processing..
• Protein Sequence: MTSTDVSSGVSNCYVFKSRLQEYAQKYKLPTPVYEIVKEGPSHKSLFQSTVILDGVRYNSLPGFFNRKAAEQSAAEVALRELAKSSELSQCVSQPVHETGLCKNLLQEYAQKMNYAIPLYQCQKVETLGRVTQFTCTVEIGGIKYTGAATRTKKDAEISAGRTALLAIQSDTKNNLANYNTQLTVLPCEKKTIQAAIPLKETVKTLKARKAQFKKKAQKGKRTVAKNPEDIIIPPQPTDHCQNDQSEKIETTPNLEPSSCMNGLKEAAFGSVETEKIETTPNLEPPSCMNGLKEAAFGSVETEKIETTPNLEPPSCMNGLKEAAFGSVETEKIETTPNLEPSSCMNGLKEAAFGSVETEKIETTPNLEPPSCMNGLKEAAFGSVETEKIETTPNLESSSCMSGLKEAAFGSVETEASHA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	AQKYKLPTPVYEIVK HHHCCCCCCHHHHHH	35.50	24894044

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DRB1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DRB1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRB1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DRB1_ARATH	HYL1	physical	17442570
DCL1_ARATH	DCL1	physical	15821876
DRB5_ARATH	DRB5	physical	15821876
DRB2_ARATH	DRB2	physical	15821876
DRB4_ARATH	DRB4	physical	15821876
DRB1_ARATH	HYL1	physical	15821876
DCL3_ARATH	DCL3	physical	15821876
DRB5_ARATH	DRB5	physical	21798944
DCL1_ARATH	DCL1	physical	24554768
HEN1_ARATH	HEN1	physical	25680966
DRB1_ARATH	HYL1	physical	25294831
DCL1_ARATH	DCL1	physical	25294831
SRRT_ARATH	SE	physical	25294831
VOZ1_ARATH	VOZ1	physical	25294831

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.