DPOLA_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPOLA_ARATH
• UniProt AC: Q9FHA3
• Protein Name: DNA polymerase alpha catalytic subunit
• Gene Name: POLA
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1524
• Subcellular Localization: Nucleus.
• Protein Description: Polymerase alpha in a complex with DNA primase is a replicative polymerase..
• Protein Sequence: MSGDNSTETGRRRSRGAEASSRKDTLERLKAIRQGGIRSASGGGYDIRLQKPIFDTVDDEEYDALVSRRREEARGFVVEDGEGGDLGYLDEGEEEDWSKPSGPESTDESDDGGRFSGRLKKKKKGKEQTQQPQVKKVNPALKAAATITGEGRLSSMFTSSSFKKVKETDKAQYEGILDEIIAQVTPDESDRKKHTRRKLPGTVPVTIFKNKKLFSVASSMGMKESEPTPSTYEGDSVSMDNELMKEEDMKESEVIPSETMELLGSDIVKEDGSNKIRKTEVKSELGVKEVFTLNATIDMKEKDSALSATAGWKEAMGKVGTENGALLGSSSEGKTEFDLDADGSLRFFILDAYEEAFGASMGTIYLFGKVKMGDTYKSCCVVVKNIQRCVYAIPNDSIFPSHELIMLEQEVKDSRLSPESFRGKLHEMASKLKNEIAQELLQLNVSNFSMAPVKRNYAFERPDVPAGEQYVLKINYSFKDRPLPEDLKGESFSALLGSHTSALEHFILKRKIMGPCWLKISSFSTCSPSEGVSWCKFEVTVQSPKDITILVSEEKVVHPPAVVTAINLKTIVNEKQNISEIVSASVLCFHNAKIDVPMPAPERKRSGILSHFTVVRNPEGTGYPIGWKKEVSDRNSKNGCNVLSIENSERALLNRLFLELNKLDSDILVGHNISGFDLDVLLQRAQACKVQSSMWSKIGRLKRSFMPKLKGNSNYGSGATPGLMSCIAGRLLCDTDLCSRDLLKEVSYSLTDLSKTQLNRDRKEIAPNDIPKMFQSSKTLVELIECGETDAWLSMELMFHLSVLPLTLQLTNISGNLWGKTLQGARAQRIEYYLLHTFHSKKFILPDKISQRMKEIKSSKRRMDYAPEDRNVDELDADLTLENDPSKGSKTKKGPAYAGGLVLEPKRGLYDKYVLLLDFNSLYPSIIQEYNICFTTIPRSEDGVPRLPSSQTPGILPKLMEHLVSIRKSVKLKMKKETGLKYWELDIRQQALKLTANSMYGCLGFSNSRFYAKPLAELITLQGRDILQRTVDLVQNHLNLEVIYGDTDSIMIHSGLDDIEEVKAIKSKVIQEVNKKYRCLKIDCDGIYKRMLLLRKKKYAAVKLQFKDGKPCEDIERKGVDMVRRDWSLLSKEIGDLCLSKILYGGSCEDVVEAIHNELMKIKEEMRNGQVALEKYVITKTLTKPPAAYPDSKSQPHVQVALRMRQRGYKEGFNAKDTVPYIICYEQGNASSASSAGIAERARHPDEVKSEGSRWLVDIDYYLAQQIHPVVSRLCAEIQGTSPERLAECLGLDPSKYRSKSNDATSSDPSTSLLFATSDEERYKSCEPLALTCPSCSTAFNCPSIISSVCASISKKPATPETEESDSTFWLKLHCPKCQQEDSTGIISPAMIANQVKRQIDGFVSMYYKGIMVCEDESCKHTTRSPNFRLLGERERGTVCPNYPNCNGTLLRKYTEADLYKQLSYFCHILDTQCSLEKMDVGVRIQVEKAMTKIRPAVKSAAAITRSSRDRCAYGWMQLTDIVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
159	Phosphorylation	RLSSMFTSSSFKKVK HHHHCCCCHHCCCCC	16.84	25561503
160	Phosphorylation	LSSMFTSSSFKKVKE HHHCCCCHHCCCCCC	36.41	25561503
161	Phosphorylation	SSMFTSSSFKKVKET HHCCCCHHCCCCCCC	40.63	19880383
949	Phosphorylation	DGVPRLPSSQTPGIL CCCCCCCCCCCCCHH	39.40	23776212
950	Phosphorylation	GVPRLPSSQTPGILP CCCCCCCCCCCCHHH	35.81	23776212
952	Phosphorylation	PRLPSSQTPGILPKL CCCCCCCCCCHHHHH	25.98	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPOLA_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPOLA_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPOLA_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLF_ARATH	CLF	genetic	17873092
LHP1_ARATH	TFL2	genetic	17873092
FAS1_ARATH	FAS1	genetic	17873092
LHP1_ARATH	TFL2	physical	17873092

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.