dbPTM

DHYS_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DHYS_SCHPO
UniProt AC	O94337
Protein Name	Probable deoxyhypusine synthase
Gene Name	SPBC1271.04c
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	350
Subcellular Localization
Protein Description	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue..
Protein Sequence	MDESLAKDAVFVASSKPSDLTTEVVGPDFNKYDERKKAGGPGITVEELVESYGKIGFQATNLHDAVTIINEMRNWRDPNPPEEKSDRATIFLGYTSNLISSGVREVLRYLVQHKCVDVIVTTAGGVEEDIIKCLGPTYVGDFHLDGKNLRAKGLNRIGNLIVPNDNYCRFEEWIFPILNKMVEEQETLGTHWTPSSFIRRLGKEINDESSVLYWAYKNNIPIYSPALTDGSIGDMLYFHTYKATPRPLVLDIVADIRNMNTHAVRANKSGIIILGGGVVKHHICNANLMRNGAEWSVYINSANEFDGSDAGARPDEAVSWGKIRGDAKKVKVYGEVSLLFPLIVAATFAK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
269	Phosphorylation	HAVRANKSGIIILGG HHHHCCCCCEEEECC	34.72	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DHYS_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DHYS_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DHYS_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHYS_SCHPO	SPBC1271.04c	physical	26771498
WDR6_SCHPO	rtt10	physical	26771498
IMA2_SCHPO	imp1	physical	26771498
IF5A2_SCHPO	tif512	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DHYS_SCHPO

Related Literatures of Post-Translational Modification