DHRSX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHRSX_HUMAN
• UniProt AC: Q8N5I4
• Protein Name: Dehydrogenase/reductase SDR family member on chromosome X
• Gene Name: DHRSX
• Organism: Homo sapiens (Human).
• Sequence Length: 330
• Subcellular Localization: Secreted . Secreted in a non-classical form. A signal peptide sequence at position 1-31 is predicted.
• Protein Description: Involved in the positive regulation of starvation-induced autophagy. [PubMed: 25076851]
• Protein Sequence: MSPLSAARAALRVYAVGAAVILAQLLRRCRGGFLEPVFPPRPDRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAWTSIYAAVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGVLDVTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPLSAARA ------CCHHHHHHH	34.25	29514088
5	Phosphorylation	---MSPLSAARAALR ---CCHHHHHHHHHH	24.22	29514088
61	Ubiquitination	GIGYSTAKHLARLGM CCCHHHHHHHHHCCC	38.96	-
260	Ubiquitination	WATRLAKKLLGWLLF HHHHHHHHHHHHHHC	43.25	33845483
302	Phosphorylation	YNEKETKSLHVTYNQ CCCCCCEEEEEEHHH	31.00	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHRSX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHRSX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHRSX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
GCNT3_HUMAN	GCNT3	physical	21988832
ZBED1_HUMAN	ZBED1	physical	26186194
ZBED1_HUMAN	ZBED1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.