DDX41_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX41_DROME
• UniProt AC: Q9V3C0
• Protein Name: ATP-dependent RNA helicase abstrakt
• Gene Name: abs
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 619
• Subcellular Localization: Nucleus .
• Protein Description: ATP-dependent RNA helicase. Is essential for the directed and fasciculated early outgrowth of the bolwig nerves, as well as for its navigation at later stages. Is required during post-transcriptional gene expression. Plays a role during morphogenetic process, apoptosis and the establishment of cell polarity..
• Protein Sequence: MAHVKRYRRSSKSSEEGDLDNEDYVPYVPVKERKKQHMIKLGRIVQLVSETAQPKSSSENENEDDSQGAHDVETWGRKYNISLLDQHTELKKIAEAKKLSAVEKQLREEEKIMESIAQQKALMGVAELAKGIQYEQPIKTAWKPPRYIREMSEEEREAVRHELRILVEGETPSPPIRSFREMKFPKGILNGLAAKGIKNPTPIQVQGLPTVLAGRDLIGIAFTGSGKTLVFVLPVIMFALEQEYSLPFERNEGPYGLIICPSRELAKQTHEIIQHYSKHLQACGMPEIRSCLAMGGLPVSEALDVISRGVHIVVATPGRLMDMLDKKILTLDMCRYLCMDEADRMIDMGFEEDVRTIFSFFKGQRQTLLFSATMPKKIQNFARSALVKPVTINVGRAGAASMNVTQQVEYVKQEAKVVYLLDCLQKTAPPVLIFAEKKQDVDCIHEYLLLKGVEAVAIHGGKDQEERSRAVDAYRVGKKDVLVATDVASKGLDFPNVQHVINYDMPDDIENYVHRIGRTGRSNTKGLATTLINKTTEQSVLLDLKHLLIEGKQEVPDFLDELAPETEHQHLDLGDSHGCTYCGGLGHRITECPKLEAVQNKQASNIGRRDYLSNTAADY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	HVKRYRRSSKSSEEG CHHHHCCCCCCCCCC	32.87	19429919
11	Phosphorylation	VKRYRRSSKSSEEGD HHHHCCCCCCCCCCC	34.44	19429919
13	Phosphorylation	RYRRSSKSSEEGDLD HHCCCCCCCCCCCCC	44.95	19429919
14	Phosphorylation	YRRSSKSSEEGDLDN HCCCCCCCCCCCCCC	43.32	19429919
56	Phosphorylation	SETAQPKSSSENENE HHCCCCCCCCCCCCC	45.86	19429919
57	Phosphorylation	ETAQPKSSSENENED HCCCCCCCCCCCCCC	48.04	19429919
58	Phosphorylation	TAQPKSSSENENEDD CCCCCCCCCCCCCCC	52.08	19429919
66	Phosphorylation	ENENEDDSQGAHDVE CCCCCCCCCCCCCHH	42.72	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX41_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX41_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX41_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NKAP_DROME	CG6066	physical	14605208
CNC_DROME	cnc	physical	14605208
CCNB_DROME	CycB	physical	14605208
PREP_DROME	CG3107	physical	22036573
RU17_DROME	snRNP-U1-70K	physical	22036573
COQ6_DROME	CG7277	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; SER-13; SER-14;SER-56; SER-57; SER-58 AND SER-66, AND MASS SPECTROMETRY.
PubMed: 18327897