DCC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCC_MOUSE
• UniProt AC: P70211
• Protein Name: Netrin receptor DCC
• Gene Name: Dcc
• Organism: Mus musculus (Mouse).
• Sequence Length: 1447
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene..
• Protein Sequence: MENSLGCVWVPKLAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCSAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLADSGSIISRTAKVTVAGPLRFLSQTESITAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLNPLPGDSRVVVLPSGALQISRLQPGDSGVYRCSARNPASIRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQLIVPKPAIPSSSILPSAPRDVLPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLHAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNISLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGVQAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNVKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVITVVTVGVLTVLVVVIVAVICTRRSSAQQRKKRATHSVSKRKGSQKDLRPPDLWIHHEEMEMKNIEKPTGTDPAGRDSPIQSCQDLTPVSHSQSETQMGSKSASHSGQDTEDAGSSMSTLERSLAARRATRAKLMIPMEAQSSNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRTQSVSEGPTTQQQPMLPPAQPEHPSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGSAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	N-linked_Glycosylation	RGGNVLLNCSAESDR ECCEEEEECCCCCCC	17.34	-
94	N-linked_Glycosylation	DRKQQLPNGSLLIQN HHHHCCCCCCCHHHH	62.37	-
232	Phosphorylation	EAEVRILSDPGLHRQ CEEEEEECCCCHHHE	39.11	22345495
241	Phosphorylation	PGLHRQLYFLQRPSN CCHHHEEEEECCCCC	8.23	22345495
247	Phosphorylation	LYFLQRPSNVIAIEG EEEECCCCCEEEEEC	46.01	22345495
299	N-linked_Glycosylation	GSNLLISNVTDDDSG CCCEEEECCCCCCCC	33.44	-
318	N-linked_Glycosylation	VVTYKNENISASAEL EEEECCCCEEEEEEE	42.80	-
478	N-linked_Glycosylation	DNRERALNTTQPGSL CCCCEECCCCCCCCE	39.84	-
505	Phosphorylation	YTFRVVAYNEWGPGE EEEEEEEECCCCCCC	11.29	29514104
604	Phosphorylation	RFLAYNRYGPGVSTD HHHHHCCCCCCCCCC	24.84	25777480
609	Phosphorylation	NRYGPGVSTDDITVV CCCCCCCCCCCEEEE	31.84	25777480
610	Phosphorylation	RYGPGVSTDDITVVT CCCCCCCCCCEEEEE	34.97	25777480
614	Phosphorylation	GVSTDDITVVTLSDV CCCCCCEEEEEHHCC	18.87	25777480
617	Phosphorylation	TDDITVVTLSDVPSA CCCEEEEEHHCCCCC	19.06	25777480
619	Phosphorylation	DITVVTLSDVPSAPP CEEEEEHHCCCCCCC	27.48	25777480
623	Phosphorylation	VTLSDVPSAPPQNIS EEHHCCCCCCCCCEE	53.94	25777480
628	N-linked_Glycosylation	VPSAPPQNISLEVVN CCCCCCCCEEEEEEC	31.43	-
630	Phosphorylation	SAPPQNISLEVVNSR CCCCCCEEEEEECCC	26.48	25777480
636	Phosphorylation	ISLEVVNSRSIKVSW EEEEEECCCCEEEEE	18.78	25777480
638	Phosphorylation	LEVVNSRSIKVSWLP EEEECCCCEEEEEEC	26.95	25777480
702	N-linked_Glycosylation	QVSAMTVNGTGPPSN EEEEEEECCCCCCCC	32.89	-
809	Phosphorylation	AGEGVPLYESATTRS CCCCCCCCCCCCCCC	11.19	-
1171	Phosphorylation	NIEKPTGTDPAGRDS CCCCCCCCCCCCCCC	41.09	29899451
1178	Phosphorylation	TDPAGRDSPIQSCQD CCCCCCCCCCCCCCC	23.65	25521595
1182	Phosphorylation	GRDSPIQSCQDLTPV CCCCCCCCCCCCCCC	17.92	-
1187	Phosphorylation	IQSCQDLTPVSHSQS CCCCCCCCCCCCCCC	29.90	-
1192	Phosphorylation	DLTPVSHSQSETQMG CCCCCCCCCCCCCCC	28.09	21082442
1215	Phosphorylation	QDTEDAGSSMSTLER CCCCCCCHHHHHHHH	25.29	29899451
1216	Phosphorylation	DTEDAGSSMSTLERS CCCCCCHHHHHHHHH	18.81	29899451
1218	Phosphorylation	EDAGSSMSTLERSLA CCCCHHHHHHHHHHH	31.61	29899451
1219	Phosphorylation	DAGSSMSTLERSLAA CCCHHHHHHHHHHHH	24.81	29899451
1267	Phosphorylation	QYPGILPSPTCGYPH CCCCCCCCCCCCCCC	29.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1178	S	Phosphorylation	Kinase	MAPK1	P63085	Uniprot
1187	T	Phosphorylation	Kinase	MAPK1	P63085	Uniprot
1267	S	Phosphorylation	Kinase	MAPK1	P63085	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCC_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF4E_MOUSE	Eif4e	physical	20434207
EIF2A_MOUSE	Eif2a	physical	20434207
EIF3E_MOUSE	Eif3e	physical	20434207
RL5_MOUSE	Rpl5	physical	20434207
RL28_MOUSE	Rpl28	physical	20434207

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.