CXCL9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXCL9_HUMAN
• UniProt AC: Q07325
• Protein Name: C-X-C motif chemokine 9
• Gene Name: CXCL9
• Organism: Homo sapiens (Human).
• Sequence Length: 125
• Subcellular Localization: Secreted.
• Protein Description: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3..
• Protein Sequence: MKKSGVLFLLGIILLVLIGVQGTPVVRKGRCSCISTNQGTIHLQSLKDLKQFAPSPSCEKIEIIATLKNGVQTCLNPDSADVKELIKKWEKQVSQKKKQKNGKKHQKKKVLKVRKSQRSRQKKTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MKKSGVLFL ------CCHHHHHHH	56.50	21669532
3	Acetylation	-----MKKSGVLFLL -----CCHHHHHHHH	51.66	21669532
4	Phosphorylation	----MKKSGVLFLLG ----CCHHHHHHHHH	28.72	25022875
23	Phosphorylation	VLIGVQGTPVVRKGR HHHCCCCCCCEECCE	8.87	25022875
28	Acetylation	QGTPVVRKGRCSCIS CCCCCEECCEEEEEE	38.81	21669532
32	Phosphorylation	VVRKGRCSCISTNQG CEECCEEEEEECCCC	17.08	29083192
35	Phosphorylation	KGRCSCISTNQGTIH CCEEEEEECCCCEEE	26.15	29083192
36	Phosphorylation	GRCSCISTNQGTIHL CEEEEEECCCCEEEE	16.20	29083192
40	Phosphorylation	CISTNQGTIHLQSLK EEECCCCEEEECCHH	8.75	29083192
45	Phosphorylation	QGTIHLQSLKDLKQF CCEEEECCHHHHHHH	43.69	29083192
97	Ubiquitination	EKQVSQKKKQKNGKK HHHHHHHHHHHCCCH	53.45	-
107	Ubiquitination	KNGKKHQKKKVLKVR HCCCHHHHHHHHHHH	55.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CXCL9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXCL9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXCL9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAX8_HUMAN	PAX8	physical	21988832
PSPC_HUMAN	SFTPC	physical	25416956
PTN5_HUMAN	PTPN5	physical	25416956
KASH5_HUMAN	CCDC155	physical	25416956
SYNE4_HUMAN	SYNE4	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.