CXA5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXA5_HUMAN
• UniProt AC: P36382
• Protein Name: Gap junction alpha-5 protein
• Gene Name: GJA5
• Organism: Homo sapiens (Human).
• Sequence Length: 358
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
• Protein Description: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell..
• Protein Sequence: MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPGCQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGSGSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVKPRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQVRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDLSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Phosphorylation	FPISHIRYWVLQIIF CCHHHHHHHHHHHHE	10.16	24043423
86	Phosphorylation	VLQIIFVSTPSLVYM HHHHHEECCHHHHHH	24.69	24043423
87	Phosphorylation	LQIIFVSTPSLVYMG HHHHEECCHHHHHHH	16.17	22210691
89	Phosphorylation	IIFVSTPSLVYMGHA HHEECCHHHHHHHHH	30.47	22210691
92	Phosphorylation	VSTPSLVYMGHAMHT ECCHHHHHHHHHHHH	11.59	24043423
99	Phosphorylation	YMGHAMHTVRMQEKR HHHHHHHHHHHHHHH	9.20	22210691
120	Phosphorylation	RAKEVRGSGSYEYPV HHHHHCCCCCCCCCC	17.63	28857561
122	Phosphorylation	KEVRGSGSYEYPVAE HHHCCCCCCCCCCCC	19.25	28857561
123	Phosphorylation	EVRGSGSYEYPVAEK HHCCCCCCCCCCCCC	24.02	-
125	Phosphorylation	RGSGSYEYPVAEKAE CCCCCCCCCCCCCEE	8.52	-
134	Phosphorylation	VAEKAELSCWEEGNG CCCCEEEEEEECCCC	14.53	28060719
260	Phosphorylation	PSVGIVQSCTPPPDF CCEEEEECCCCCCCH	14.74	27251275
262	Phosphorylation	VGIVQSCTPPPDFNQ EEEEECCCCCCCHHH	44.04	27251275
345	Phosphorylation	HSDKRRLSKASSKAR CCCHHHHHHHHHHHH	25.10	10728420
353	Phosphorylation	KASSKARSDDLSV-- HHHHHHHHCCCCC--	40.09	24719451
357	Phosphorylation	KARSDDLSV------ HHHHCCCCC------	32.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CXA5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXA5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXA5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AAR2_HUMAN	AAR2	physical	16189514
RIMS3_HUMAN	RIMS3	physical	21988832
MARK1_HUMAN	MARK1	physical	21988832
UBQL4_HUMAN	UBQLN4	physical	25583071
PSMD2_HUMAN	PSMD2	physical	25583071

Drug and Disease Associations

• Kegg Disease
• H00731: Atrial fibrillation
• OMIM Disease
• 108770: Atrial standstill 1 (ATRST1)
• 614049: Atrial fibrillation, familial, 11 (ATFB11)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.