RIMS3_HUMAN - dbPTM
RIMS3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RIMS3_HUMAN
UniProt AC Q9UJD0
Protein Name Regulating synaptic membrane exocytosis protein 3
Gene Name RIMS3
Organism Homo sapiens (Human).
Sequence Length 308
Subcellular Localization Cell junction, synapse.
Protein Description Regulates synaptic membrane exocytosis..
Protein Sequence MFNGEPGPASSGASRNVVRSSSISGEICGSQQAGGGAGTTTAKKRRSSLGAKMVAIVGLTQWSKSTLQLPQPEGATKKLRSNIRRSTETGIAVEMRSRVTRQGSRESTDGSTNSNSSDGTFIFPTTRLGAESQFSDFLDGLGPAQIVGRQTLATPPMGDVHIAIMDRSGQLEVEVIEARGLTPKPGSKSLPATYIKVYLLENGACLAKKKTKMTKKTCDPLYQQALLFDEGPQGKVLQVIVWGDYGRMDHKCFMGMAQIMLDELDLSAAVTGWYKLFPTSSVADSTLGSLTRRLSQSSLESATSPSCS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationNGEPGPASSGASRNV
CCCCCCCCCCCCCCE		32.2222210691
11PhosphorylationGEPGPASSGASRNVV
CCCCCCCCCCCCCEE		40.2522210691
14PhosphorylationGPASSGASRNVVRSS
CCCCCCCCCCEECCC		28.1022210691
20PhosphorylationASRNVVRSSSISGEI
CCCCEECCCCCCCEE		19.4829978859
21PhosphorylationSRNVVRSSSISGEIC
CCCEECCCCCCCEEC		22.5629978859
22PhosphorylationRNVVRSSSISGEICG
CCEECCCCCCCEECC		23.2429978859
24PhosphorylationVVRSSSISGEICGSQ
EECCCCCCCEECCCC		32.1127251275
47PhosphorylationTTAKKRRSSLGAKMV
HHHHHHHHHHCCCEE		33.6721406692
48PhosphorylationTAKKRRSSLGAKMVA
HHHHHHHHHCCCEEE		29.0721406692
60PhosphorylationMVAIVGLTQWSKSTL
EEEEEECCCCCHHCC		23.2820068231
63PhosphorylationIVGLTQWSKSTLQLP
EEECCCCCHHCCCCC		13.6020068231
65PhosphorylationGLTQWSKSTLQLPQP
ECCCCCHHCCCCCCC		28.9127732954
66PhosphorylationLTQWSKSTLQLPQPE
CCCCCHHCCCCCCCC		23.4327732954
97PhosphorylationGIAVEMRSRVTRQGS
CEEEEECCCCCCCCC		29.77-
104PhosphorylationSRVTRQGSRESTDGS
CCCCCCCCCCCCCCC		25.2430624053
107PhosphorylationTRQGSRESTDGSTNS
CCCCCCCCCCCCCCC		30.5930624053
108PhosphorylationRQGSRESTDGSTNSN
CCCCCCCCCCCCCCC		39.3630576142
111PhosphorylationSRESTDGSTNSNSSD
CCCCCCCCCCCCCCC		27.5030576142
112PhosphorylationRESTDGSTNSNSSDG
CCCCCCCCCCCCCCC		48.4727732954
114PhosphorylationSTDGSTNSNSSDGTF
CCCCCCCCCCCCCCE		37.8727732954
116PhosphorylationDGSTNSNSSDGTFIF
CCCCCCCCCCCCEEE		29.6227732954
117PhosphorylationGSTNSNSSDGTFIFP
CCCCCCCCCCCEEEE		44.2927732954
125PhosphorylationDGTFIFPTTRLGAES
CCCEEEECCCCCCHH		17.5030576142
126PhosphorylationGTFIFPTTRLGAESQ
CCEEEECCCCCCHHH		24.92-
132PhosphorylationTTRLGAESQFSDFLD
CCCCCCHHHHHHHHC		35.6722210691
135PhosphorylationLGAESQFSDFLDGLG
CCCHHHHHHHHCCCC		21.5922210691
189PhosphorylationTPKPGSKSLPATYIK
CCCCCCCCCCCEEEE		41.0829978859
193PhosphorylationGSKSLPATYIKVYLL
CCCCCCCEEEEEEEH		24.6829978859
194PhosphorylationSKSLPATYIKVYLLE
CCCCCCEEEEEEEHH		10.8029978859
198PhosphorylationPATYIKVYLLENGAC
CCEEEEEEEHHCCCE		10.6829978859
216UbiquitinationKKTKMTKKTCDPLYQ
CCCCCCHHHCCHHHH		45.2629967540
222PhosphorylationKKTCDPLYQQALLFD
HHHCCHHHHHHHHHC		12.17-
245PhosphorylationQVIVWGDYGRMDHKC
EEEEEECCCCCCHHH		11.5917081983
274PhosphorylationSAAVTGWYKLFPTSS
HHHHHCHHHHCCCCH		10.1222210691
285PhosphorylationPTSSVADSTLGSLTR
CCCHHHHHHHHHHHH		18.7826074081
286PhosphorylationTSSVADSTLGSLTRR
CCHHHHHHHHHHHHH		35.3726074081
289PhosphorylationVADSTLGSLTRRLSQ
HHHHHHHHHHHHHHH		29.6722210691
291PhosphorylationDSTLGSLTRRLSQSS
HHHHHHHHHHHHHHH		18.5526074081
295PhosphorylationGSLTRRLSQSSLESA
HHHHHHHHHHHHHHC		26.6317525332
297PhosphorylationLTRRLSQSSLESATS
HHHHHHHHHHHHCCC		33.2530266825
298PhosphorylationTRRLSQSSLESATSP
HHHHHHHHHHHCCCC		28.6330266825
301PhosphorylationLSQSSLESATSPSCS
HHHHHHHHCCCCCCC		41.9830266825
303PhosphorylationQSSLESATSPSCS--
HHHHHHCCCCCCC--		50.9130266825
304PhosphorylationSSLESATSPSCS---
HHHHHCCCCCCC---		17.9630266825
306PhosphorylationLESATSPSCS-----
HHHCCCCCCC-----		27.1026552605
308PhosphorylationSATSPSCS-------
HCCCCCCC-------		47.8226552605
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RIMS3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RIMS3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RIMS3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BANP_HUMANBANPphysical
24722188
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RIMS3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-245, AND MASSSPECTROMETRY.

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