CSN5_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSN5_CAEEL
• UniProt AC: P91001
• Protein Name: COP9 signalosome complex subunit 5
• Gene Name: csn-5
• Organism: Caenorhabditis elegans.
• Sequence Length: 368
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3. May stabilize glh-1 protein levels by antagonizing kgb-1. [PubMed: 17699606]
• Protein Sequence: MEVDNVKPSSSVPQRNWEKENNVQNVDSIFEYNNKQQVEIRNAKPWDKDPHYFKQIKISAIALLKMTMHAKRGGNLEIMGLLQGRIDANSFIILDVFALPVEGTETRVNAQAQAYEYMTVYSEMCDTEGRKEKVVGWYHSHPGYGCWLSGIDVSTQTLNQKFQEPWVAIVIDPLRTMSAGKVDIGAFRTYPEGYRPPDDVPSEYQSIPLAKIEDFGVHCKRYYSLDVSFFKSQLDAHILTSLWNSYWISTLSSSPLFSNVEFLNNQIQDINQKLSAVDKKLQLNDRSVDGHEALMKVVTDAKAVGDELETGRISHLVKQLLFARQAGGGCGCSHASAGSPMDIAVATEPEKAGPSPSAPEPAVEMADA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
333	Phosphorylation	AGGGCGCSHASAGSP CCCCCCCCCCCCCCC	13.84	19530675
336	Phosphorylation	GCGCSHASAGSPMDI CCCCCCCCCCCCCCE	27.95	19530675
339	Phosphorylation	CSHASAGSPMDIAVA CCCCCCCCCCCEEEE	19.44	19060867
355	Phosphorylation	EPEKAGPSPSAPEPA CHHHCCCCCCCCCCC	30.48	28854356
357	Phosphorylation	EKAGPSPSAPEPAVE HHCCCCCCCCCCCHH	61.87	28854356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSN5_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSN5_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSN5_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN2_CAEEL	csn-2	physical	17403899
CSN1_CAEEL	csn-1	physical	17403899
CSN3_CAEEL	csn-3	physical	17403899
CSN4_CAEEL	csn-4	physical	17403899
CSN6_CAEEL	csn-6	physical	17403899
CSN5_CAEEL	csn-5	physical	17403899
CUL3_CAEEL	cul-3	physical	17403899
EIF3M_CAEEL	cif-1	physical	17403899

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.