EIF3M_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF3M_CAEEL
• UniProt AC: Q94261
• Protein Name: COP9/Signalosome and eIF3 complex-shared subunit 1 {ECO:0000255|HAMAP-Rule:MF_03012}
• Gene Name: cif-1 {ECO:0000255|HAMAP-Rule:MF_03012}
• Organism: Caenorhabditis elegans.
• Sequence Length: 390
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. [PubMed: 17403899 The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF]
• Protein Sequence: MADTRELPVFAYIDDVKQLQELRQYLNKHDSVKLDPNGPSETAQNMIEICSTLNVLPSWSQDVDLVLNSISSLIVVVPGEKCEPVVDSFIKNVAPQFYKGTGWASHAGIAVRVLSNLYKGYSNFHTVQEKIFKALVDMCAEARLIGELECNLETLQDRFNTWKTPVEGQREILRAVHRALLVDQRVDQAAKVMTALLGTYTEKDAAAARDDAMECVRTAVVDPKSFSFDHLERLSAVKALKTSDPLMFTALELFISGTLKDYKEFVAKNPKFVTEHLKVDETILLKKIRLLTLMSLAEEKNEISLDELAKQLDILADETLEEFVIDAIQVNAISGKINEMARTLIVSSYQHRRFGTEQWVLLEKRLKVLIANLKQTHNNVHEVNQRIEAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	Phosphorylation	KNVAPQFYKGTGWAS HHHCCHHHCCCCCHH	11.85	21082442
349	Phosphorylation	RTLIVSSYQHRRFGT HHHHHHCHHHHCCCC	10.79	27067626

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF3M_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF3M_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF3M_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIR2_CAEEL	rnr-2	physical	14704431
EIF3F_CAEEL	eif-3.F	physical	17403899

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.