| UniProt ID | CRF_HUMAN | |
|---|---|---|
| UniProt AC | P06850 | |
| Protein Name | Corticoliberin | |
| Gene Name | CRH | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 196 | |
| Subcellular Localization | Secreted . | |
| Protein Description | Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).. | |
| Protein Sequence | MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLLLPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 125 | Phosphorylation | QLLLPRRSLDSPAAL HHHCCCCCCCCHHHH | 37.50 | 24719451 | |
| 194 | Isoleucine amide | NRKLMEIIGK----- CHHHHHHHCC----- | 3.52 | - | |
| 194 | Amidation | NRKLMEIIGK----- CHHHHHHHCC----- | 3.52 | 6605851 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CRF_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CRF_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CRF_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CRFR2_HUMAN | CRHR2 | physical | 8243338 | |
| CRFR1_HUMAN | CRHR1 | physical | 10598591 | |
| CRFR1_HUMAN | CRHR1 | physical | 9423932 | |
| CRFR1_RAT | Crhr1 | physical | 9423932 | |
| CRFR2_RAT | Crhr2 | physical | 9423932 | |
| K1H1_HUMAN | KRT31 | physical | 25416956 | |
| UBR1_HUMAN | UBR1 | physical | 28514442 | |
| RRAS_HUMAN | RRAS | physical | 28514442 |
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB01285 | Corticotropin |
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