CRFR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRFR2_HUMAN
• UniProt AC: Q13324
• Protein Name: Corticotropin-releasing factor receptor 2
• Gene Name: CRHR2
• Organism: Homo sapiens (Human).
• Sequence Length: 411
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels..
• Protein Sequence: MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	N-linked_Glycosylation	LHSLLEANCSLALAE HHHHHHHHHHHHHHH	13.41	UniProtKB CARBOHYD
41	N-linked_Glycosylation	EGPYSYCNTTLDQIG CCCCHHCCCCHHHCC	28.06	UniProtKB CARBOHYD
73	Phosphorylation	EYFNGVKYNTTRNAY HHHCCCCCCCCHHHH	18.48	26657352
74	N-linked_Glycosylation	YFNGVKYNTTRNAYR HHCCCCCCCCHHHHH	29.29	UniProtKB CARBOHYD
75	Phosphorylation	FNGVKYNTTRNAYRE HCCCCCCCCHHHHHH	24.84	26657352
76	Phosphorylation	NGVKYNTTRNAYREC CCCCCCCCHHHHHHH	20.49	26657352
86	N-linked_Glycosylation	AYRECLENGTWASKI HHHHHHHCCCEECCC	40.00	UniProtKB CARBOHYD
94	N-linked_Glycosylation	GTWASKINYSQCEPI CCEECCCCHHHCCCC	33.85	UniProtKB CARBOHYD
297	Phosphorylation	LMTKLRASTTSETIQ HHHHHHCCCCHHHHH	26.28	23863939
298	Phosphorylation	MTKLRASTTSETIQY HHHHHCCCCHHHHHH	33.10	29978859
299	Phosphorylation	TKLRASTTSETIQYR HHHHCCCCHHHHHHH	23.28	29978859
300	Phosphorylation	KLRASTTSETIQYRK HHHCCCCHHHHHHHH	32.60	29978859
302	Phosphorylation	RASTTSETIQYRKAV HCCCCHHHHHHHHHH	17.10	29978859
305	Phosphorylation	TTSETIQYRKAVKAT CCHHHHHHHHHHHHH	15.38	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRFR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRFR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRFR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.