CO9A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO9A1_HUMAN
• UniProt AC: P20849
• Protein Name: Collagen alpha-1(IX) chain
• Gene Name: COL9A1
• Organism: Homo sapiens (Human).
• Sequence Length: 921
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Structural component of hyaline cartilage and vitreous of the eye..
• Protein Sequence: MKTCWKIPVFFFVCSFLEPWASAAVKRRPRFPVNSNSNGGNELCPKIRIGQDDLPGFDLISQFQVDKAASRRAIQRVVGSATLQVAYKLGNNVDFRIPTRNLYPSGLPEEYSFLTTFRMTGSTLKKNWNIWQIQDSSGKEQVGIKINGQTQSVVFSYKGLDGSLQTAAFSNLSSLFDSQWHKIMIGVERSSATLFVDCNRIESLPIKPRGPIDIDGFAVLGKLADNPQVSVPFELQWMLIHCDPLRPRRETCHELPARITPSQTTDERGPPGEQGPPGPPGPPGVPGIDGIDGDRGPKGPPGPPGPAGEPGKPGAPGKPGTPGADGLTGPDGSPGSIGSKGQKGEPGVPGSRGFPGRGIPGPPGPPGTAGLPGELGRVGPVGDPGRRGPPGPPGPPGPRGTIGFHDGDPLCPNACPPGRSGYPGLPGMRGHKGAKGEIGEPGRQGHKGEEGDQGELGEVGAQGPPGAQGLRGITGIVGDKGEKGARGLDGEPGPQGLPGAPGDQGQRGPPGEAGPKGDRGAEGARGIPGLPGPKGDTGLPGVDGRDGIPGMPGTKGEPGKPGPPGDAGLQGLPGVPGIPGAKGVAGEKGSTGAPGKPGQMGNSGKPGQQGPPGEVGPRGPQGLPGSRGELGPVGSPGLPGKLGSLGSPGLPGLPGPPGLPGMKGDRGVVGEPGPKGEQGASGEEGEAGERGELGDIGLPGPKGSAGNPGEPGLRGPEGSRGLPGVEGPRGPPGPRGVQGEQGATGLPGVQGPPGRAPTDQHIKQVCMRVIQEHFAEMAASLKRPDSGATGLPGRPGPPGPPGPPGENGFPGQMGIRGLPGIKGPPGALGLRGPKGDLGEKGERGPPGRGPNGLPGAIGLPGDPGPASYGRNGRDGERGPPGVAGIPGVPGPPGPPGLPGFCEPASCTMQAGQRAFNKGPDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	AIQRVVGSATLQVAY HHHHHHCCCHHHHHH	13.38	30622161
82	Phosphorylation	QRVVGSATLQVAYKL HHHHCCCHHHHHHHC	21.30	30622161
87	Phosphorylation	SATLQVAYKLGNNVD CCHHHHHHHCCCCCC	14.11	30622161
171	N-linked_Glycosylation	LQTAAFSNLSSLFDS HHHHHHHCHHHHHHH	37.17	UniProtKB CARBOHYD
203	Phosphorylation	VDCNRIESLPIKPRG EECCCEECCCCCCCC	36.75	24719451
260	Phosphorylation	HELPARITPSQTTDE HCCCCCCCCCCCCCC	16.01	29083192
262	Phosphorylation	LPARITPSQTTDERG CCCCCCCCCCCCCCC	31.35	29083192
264	Phosphorylation	ARITPSQTTDERGPP CCCCCCCCCCCCCCC	40.32	29083192
265	Phosphorylation	RITPSQTTDERGPPG CCCCCCCCCCCCCCC	28.38	29083192
719	Phosphorylation	GLRGPEGSRGLPGVE CCCCCCCCCCCCCCC	22.85	24275569
780	Phosphorylation	HFAEMAASLKRPDSG HHHHHHHHCCCCCCC	25.53	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO9A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO9A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO9A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CO2A1_HUMAN	COL2A1	physical	11724554
PYRG2_HUMAN	CTPS2	physical	26186194
CO2A1_HUMAN	COL2A1	physical	26186194
CO6A2_HUMAN	COL6A2	physical	26186194
CO6A1_HUMAN	COL6A1	physical	26186194
CO4A2_HUMAN	COL4A2	physical	26186194
PP12C_HUMAN	PPP1R12C	physical	26186194
VHL_HUMAN	VHL	physical	26186194
PP12C_HUMAN	PPP1R12C	physical	28514442
VHL_HUMAN	VHL	physical	28514442
CO2A1_HUMAN	COL2A1	physical	28514442
CO6A1_HUMAN	COL6A1	physical	28514442
CO6A2_HUMAN	COL6A2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.