CIPK3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CIPK3_ARATH
• UniProt AC: Q2V452
• Protein Name: CBL-interacting serine/threonine-protein kinase 3
• Gene Name: CIPK3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 441
• Protein Description: Involved in the resistance to some abiotic stresses (e.g. high salt, hyperosmotic stress) in young seedlings, by regulating the expression of several stress-inducible genes (cold- and salt-induced genes but not drought-responsive genes). Required for the ABA response during germination. CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner. The CBL9/CIPK3 complex acts in the regulation of abscisic acid response in seed germination..
• Protein Sequence: MNRRQQVKRRVGKYEVGRTIGEGTFAKVKFARNSETGEPVALKILDKEKVLKHKMAEQIRREIATMKLIKHPNVVQLYEVMASKTKIFIILEYVTGGELFDKIVNDGRMKEDEARRYFQQLIHAVDYCHSRGVYHRDLKPENLLLDSYGNLKISDFGLSALSQQVRDDGLLHTSCGTPNYVAPEVLNDRGYDGATADMWSCGVVLYVLLAGYLPFDDSNLMNLYKKISSGEFNCPPWLSLGAMKLITRILDPNPMTRVTPQEVFEDEWFKKDYKPPVFEERDDSNMDDIDAVFKDSEEHLVTEKREEQPAAINAFEIISMSRGLNLENLFDPEQEFKRETRITLRGGANEIIEKIEEAAKPLGFDVQKKNYKMRLENVKAGRKGNLNVATEIFQVAPSLHMVQVSKSKGDTLEFHKFYKKLSNSLEQVVWTNNEVKKETAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
173	Phosphorylation	RDDGLLHTSCGTPNY CCCCCEECCCCCCCC	26.19	30407730
174	Phosphorylation	DDGLLHTSCGTPNYV CCCCEECCCCCCCCC	10.37	30407730
177	Phosphorylation	LLHTSCGTPNYVAPE CEECCCCCCCCCCHH	16.82	23572148
411	Phosphorylation	VSKSKGDTLEFHKFY EECCCCCHHHHHHHH	36.53	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CIPK3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CIPK3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CIPK3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNBL1_ARATH	CBL1	physical	11115898
CIPK3_ARATH	CIPK3	physical	22253446
PUB10_ARATH	AT1G71020	physical	21423366
CNBL7_ORYSJ	Os02g0291000	physical	24970010
CNBL4_ORYSJ	Os05g0534400	physical	24970010

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.