CDPK3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDPK3_ARATH
• UniProt AC: Q42479
• Protein Name: Calcium-dependent protein kinase 3
• Gene Name: CPK3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 529
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: May play a role in signal transduction pathways that involve calcium as a second messenger. Functions in abscisic acid (ABA) regulation of guard cell S-type anion-and Ca(2+)-permeable channels and stomatal closure..
• Protein Sequence: MGHRHSKSKSSDPPPSSSSSSSGNVVHHVKPAGERRGSSGSGTVGSSGSGTGGSRSTTSTQQNGRILGRPMEEVRRTYEFGRELGRGQFGVTYLVTHKETKQQVACKSIPTRRLVHKDDIEDVRREVQIMHHLSGHRNIVDLKGAYEDRHSVNLIMELCEGGELFDRIISKGLYSERAAADLCRQMVMVVHSCHSMGVMHRDLKPENFLFLSKDENSPLKATDFGLSVFFKPGDKFKDLVGSAYYVAPEVLKRNYGPEADIWSAGVILYILLSGVPPFWGENETGIFDAILQGQLDFSADPWPALSDGAKDLVRKMLKYDPKDRLTAAEVLNHPWIREDGEASDKPLDNAVLSRMKQFRAMNKLKKMALKVIAENLSEEEIIGLKEMFKSLDTDNNGIVTLEELRTGLPKLGSKISEAEIRQLMEAADMDGDGSIDYLEFISATMHMNRIEREDHLYTAFQFFDNDNSGYITMEELELAMKKYNMGDDKSIKEIIAEVDTDRDGKINYEEFVAMMKKGNPELVPNRRRM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGHRHSKSK ------CCCCCCCCC	26.91	-
16	Phosphorylation	KSSDPPPSSSSSSSG CCCCCCCCCCCCCCC	48.93	25561503
17	Phosphorylation	SSDPPPSSSSSSSGN CCCCCCCCCCCCCCC	39.76	25561503
18	Phosphorylation	SDPPPSSSSSSSGNV CCCCCCCCCCCCCCE	38.28	25561503
19	Phosphorylation	DPPPSSSSSSSGNVV CCCCCCCCCCCCCEE	35.87	25561503
20	Phosphorylation	PPPSSSSSSSGNVVH CCCCCCCCCCCCEEE	30.39	25561503
21	Phosphorylation	PPSSSSSSSGNVVHH CCCCCCCCCCCEEEE	44.18	25561503
22	Phosphorylation	PSSSSSSSGNVVHHV CCCCCCCCCCEEEEE	36.01	25561503
38	Phosphorylation	PAGERRGSSGSGTVG CCCCCCCCCCCCCCC	29.70	23776212
39	Phosphorylation	AGERRGSSGSGTVGS CCCCCCCCCCCCCCC	39.54	23776212
41	Phosphorylation	ERRGSSGSGTVGSSG CCCCCCCCCCCCCCC	32.99	23776212
43	Phosphorylation	RGSSGSGTVGSSGSG CCCCCCCCCCCCCCC	24.32	23776212
46	Phosphorylation	SGSGTVGSSGSGTGG CCCCCCCCCCCCCCC	27.47	23776212
47	Phosphorylation	GSGTVGSSGSGTGGS CCCCCCCCCCCCCCC	30.92	23776212
49	Phosphorylation	GTVGSSGSGTGGSRS CCCCCCCCCCCCCCC	34.82	23776212
51	Phosphorylation	VGSSGSGTGGSRSTT CCCCCCCCCCCCCCC	39.81	23776212
54	Phosphorylation	SGSGTGGSRSTTSTQ CCCCCCCCCCCCCCC	25.14	23776212
77	Phosphorylation	PMEEVRRTYEFGREL CHHHHHHHHHHHHHH	19.48	29654922
242	Phosphorylation	KFKDLVGSAYYVAPE HHHHHCCHHHEECHH	12.96	-
377	Phosphorylation	KVIAENLSEEEIIGL HHHHHCCCHHHHHCH	55.32	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDPK3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDPK3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDPK3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APX3_ARATH	APX3	physical	22789293
ORP2A_ARATH	ORP2A	physical	22789293
HMGB5_ARATH	HMGB5	physical	22789293
KCO1_ARATH	ATKCO1	physical	23253603
KCAB_ARATH	KAB1	physical	23253603
ADF1_ARATH	ADF1	physical	23903947
LRK32_ARATH	AT2G29250	physical	24833385
Y2393_ARATH	AT2G39360	physical	24833385
SKS1_ARATH	SKS1	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.