CDC27_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDC27_RAT
• UniProt AC: Q4V8A2
• Protein Name: Cell division cycle protein 27 homolog
• Gene Name: Cdc27
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 824
• Subcellular Localization: Nucleus.
• Protein Description: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)..
• Protein Sequence: MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTALVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVISPDNVPLGTGPSILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVPSTGAPTKKSVARMGHTGAKSVFSQSGNSREATPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
205	Phosphorylation	PETVLTETPQDTIEL CCCEEECCCCCCEEE	22.48	-
209	Phosphorylation	LTETPQDTIELNRLN EECCCCCCEEECCCC	15.88	-
291	Phosphorylation	ILPLETPSPGDGSYL EEECCCCCCCCCCCC	49.27	-
313	Phosphorylation	SVIDVPSTGAPTKKS CEECCCCCCCCCHHH	31.15	-
336	Phosphorylation	AKSVFSQSGNSREAT CHHHHCCCCCCCCCC	38.45	27097102
339	Phosphorylation	VFSQSGNSREATPVL HHCCCCCCCCCCCEE	34.72	27097102
343	Phosphorylation	SGNSREATPVLVAQT CCCCCCCCCEEEEEE	14.80	27097102
350	Phosphorylation	TPVLVAQTQSSGPQT CCEEEEEECCCCCCC	22.23	27097102
352	Phosphorylation	VLVAQTQSSGPQTST EEEEEECCCCCCCCC	40.42	27097102
353	Phosphorylation	LVAQTQSSGPQTSTT EEEEECCCCCCCCCC	44.68	27097102
357	Phosphorylation	TQSSGPQTSTTPQVL ECCCCCCCCCCCCCC	31.04	27097102
358	Phosphorylation	QSSGPQTSTTPQVLS CCCCCCCCCCCCCCC	25.65	27097102
359	Phosphorylation	SSGPQTSTTPQVLSP CCCCCCCCCCCCCCC	45.97	27097102
360	Phosphorylation	SGPQTSTTPQVLSPT CCCCCCCCCCCCCCC	16.10	27097102
365	Phosphorylation	STTPQVLSPTITSPP CCCCCCCCCCCCCCC	22.57	27097102
367	Phosphorylation	TPQVLSPTITSPPNA CCCCCCCCCCCCCCC	33.25	27097102
369	Phosphorylation	QVLSPTITSPPNALP CCCCCCCCCCCCCCC	37.34	27097102
370	Phosphorylation	VLSPTITSPPNALPR CCCCCCCCCCCCCCC	34.21	27097102
380	Phosphorylation	NALPRRSSRLFTSDS CCCCCCCCCCCCCCC	31.06	-
387	Phosphorylation	SRLFTSDSSTTKENS CCCCCCCCCCCHHHH	29.38	-
427	Phosphorylation	TQPNINDSLEITKLD CCCCCCCCEEEEECC	24.34	28432305
431	Phosphorylation	INDSLEITKLDSSII CCCCEEEEECCHHHH	19.04	28432305
436	Phosphorylation	EITKLDSSIISEGKI EEEECCHHHHCCCCC	24.49	-
439	Phosphorylation	KLDSSIISEGKISTI ECCHHHHCCCCCCCC	38.33	-
447	Phosphorylation	EGKISTITPQIQAFN CCCCCCCCHHHHHHC	14.83	-
821	Phosphorylation	TQLHAAESDEF---- CHHHHHHCCCC----	37.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDC27_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
427	S	Phosphorylation	Phosphorylation on Ser-427 and Thr-447 occurs specifically during mitosis (By similarity).	-
447	T	Phosphorylation	Phosphorylation on Ser-427 and Thr-447 occurs specifically during mitosis (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDC27_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RASK_RAT	Kras	physical	22045811
CDC20_RAT	Cdc20	physical	22045811
CADH1_RAT	Cdh1	physical	11340163

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.