CADH1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CADH1_RAT
• UniProt AC: Q9R0T4
• Protein Name: Cadherin-1
• Gene Name: Cdh1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 886
• Subcellular Localization: Cell junction . Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through associa
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity)..
• Protein Sequence: MGARCRSFSALLLLLQVSSWLCQQPESESDSCRPGFSSEVYTFLVPERHLERGHILGRVKFEGCTGRPRTAFFSEDSRFKVSTDGVITVKRHLKLHKLETSFLVHAWDSSYRKLSTKVTLKSLGHHHHRHHHRDPVSESNPELLTFPSFHQGLRRQKRDWVIPPINCPENQKGEFPQRLVQIKSNRDKETTVFYSITGPGADKPPVGVFIIERETGWLKVTQPLDREAIDKYLLYSHAVSSNGEAVEDPMEIVVTVTDQNDNRPEFIQEVFEGSVAEGALPGTSVMQVSATDADDDINTYNAAIAYTILSQDPELPHKNMFTVNRDTGVISVVTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPIFNPSTYQGQVLENEVGARIATLKVTDDDAPNTPAWNAVYTVVNDPDHQFTVITDPKTNEGILKTAKGLDFEAKQQYILHVTVENEEPFEGSLVPSTATVTVDVVDVNEAPIFVPAEKRVEVPEDFGVGLEIASYTAREPDTFMEQKITYRIWRDTANWLEINPETGVISTRAEMDREDSEHVKNSTYTALIIATDDGSPIATGTGTLLLVLSDVNDNAPIPEPRNMQFCQRNPKPHVITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAEQESLILQPRKDLEIGEYKINLKLSDNQNKDQVTTLEVHVCDCEGTVNNCMKAISLEAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVIRNDVAPTLMSMPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
284	O-linked_Glycosylation	EGALPGTSVMQVSAT CCCCCCCCEEEEEEC	22.85	-
289	O-linked_Glycosylation	GTSVMQVSATDADDD CCCEEEEEECCCCCC	14.46	-
362	O-linked_Glycosylation	QGEGLSTTAKAVITV CCCCCCCCEEEEEEE	23.84	-
474	O-linked_Glycosylation	EGSLVPSTATVTVDV CCCCCCCCCEEEEEE	21.93	-
476	O-linked_Glycosylation	SLVPSTATVTVDVVD CCCCCCCEEEEEEEE	19.46	-
513	O-linked_Glycosylation	GLEIASYTAREPDTF CEEEEEEEECCCCCH	19.42	-
562	N-linked_Glycosylation	EDSEHVKNSTYTALI CCCHHHCCCCEEEEE	38.20	-
580	O-linked_Glycosylation	DDGSPIATGTGTLLL CCCCCCCCCCCEEEE	35.68	-
582	O-linked_Glycosylation	GSPIATGTGTLLLVL CCCCCCCCCEEEEEE	23.73	-
584	O-linked_Glycosylation	PIATGTGTLLLVLSD CCCCCCCEEEEEEEC	17.67	-
641	N-linked_Glycosylation	LTHGASVNWTIEYND ECCCCEEEEEEEECC	27.90	-
752	Phosphorylation	LLPPDDDTRDNVYYY CCCCCCCCCCCEEEE	47.09	30181290
757	Phosphorylation	DDTRDNVYYYDEEGG CCCCCCEEEECCCCC	11.54	22276854
758	Phosphorylation	DTRDNVYYYDEEGGG CCCCCEEEECCCCCC	10.52	-
759	Phosphorylation	TRDNVYYYDEEGGGE CCCCEEEECCCCCCC	10.13	-
774	Phosphorylation	EDQDFDLSQLHRGLD CCCCCCHHHHHCCCC	32.32	-
797	Phosphorylation	DVAPTLMSMPQYRPR CCHHHHHCCCCCCCC	30.35	-
842	Phosphorylation	LVFDYEGSGSEAASL EEEECCCCCCCCCCH	27.49	-
844	Phosphorylation	FDYEGSGSEAASLSS EECCCCCCCCCCHHH	26.26	-
850	Phosphorylation	GSEAASLSSLNSSES CCCCCCHHHCCCCCC	30.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
757	Y	Phosphorylation	Kinase	SRC	Q9WUD9	Uniprot
758	Y	Phosphorylation	Kinase	SRC	Q9WUD9	Uniprot
759	Y	Phosphorylation	Kinase	SRC	Q9WUD9	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
641	N	Glycosylation	N-glycosylation at Asn-641 is essential for expression, folding and trafficking.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CADH1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCNA1_RAT	Ccna1	physical	11340163

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.