CDC27_MOUSE - dbPTM
CDC27_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDC27_MOUSE
UniProt AC A2A6Q5
Protein Name Cell division cycle protein 27 homolog
Gene Name Cdc27
Organism Mus musculus (Mouse).
Sequence Length 825
Subcellular Localization Nucleus.
Protein Description Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)..
Protein Sequence MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVAPTGAPTKKSVARMGQTGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGLTQPSINDSLEITKLDSSIISEGKITTVTPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
62UbiquitinationYKAYRLLKGHSCTTP
HHHHHHHCCCCCCCH		60.20-
203PhosphorylationRQPETVLTETPQDTI
CCCCCEEECCCCCCE		33.2128066266
205PhosphorylationPETVLTETPQDTIEL
CCCEEECCCCCCEEE		22.4828066266
209PhosphorylationLTETPQDTIELNRLN
EECCCCCCEEECCCC		15.8828066266
219PhosphorylationLNRLNLESSNSKYSL
ECCCCCCCCCCCEEE		37.6827566939
237PhosphorylationSSVSYIDSTVISPDN
CCCEEEECEEECCCC		18.2726745281
238PhosphorylationSVSYIDSTVISPDNV
CCEEEECEEECCCCC		20.3626745281
241PhosphorylationYIDSTVISPDNVPLG
EEECEEECCCCCCCC		23.1226745281
251PhosphorylationNVPLGPGTAILSKQV
CCCCCCCHHHHCHHH		17.4126745281
255PhosphorylationGPGTAILSKQVQNKP
CCCHHHHCHHHCCCC		18.2226745281
291PhosphorylationILPLETPSPGDGSYL
EEECCCCCCCCCCCC		49.27-
313PhosphorylationSVIDVAPTGAPTKKS
CEEEECCCCCCCHHH		35.92-
331PhosphorylationMGQTGTKSVFSQSGN
CCCCCCCCHHCCCCC		28.3829472430
334PhosphorylationTGTKSVFSQSGNSRE
CCCCCHHCCCCCCCE		22.6829472430
336PhosphorylationTKSVFSQSGNSREVT
CCCHHCCCCCCCEEE		38.4528066266
339PhosphorylationVFSQSGNSREVTPVL
HHCCCCCCCEEEEEE		33.0928066266
343PhosphorylationSGNSREVTPVLVAQT
CCCCCEEEEEEEEEE		11.7025619855
350PhosphorylationTPVLVAQTQSSGPQT
EEEEEEEECCCCCCC		22.2325619855
352PhosphorylationVLVAQTQSSGPQTST
EEEEEECCCCCCCCC		40.4225619855
353PhosphorylationLVAQTQSSGPQTSTT
EEEEECCCCCCCCCC		44.6825619855
357PhosphorylationTQSSGPQTSTTPQVL
ECCCCCCCCCCCCCC		31.0425619855
358PhosphorylationQSSGPQTSTTPQVLS
CCCCCCCCCCCCCCC		25.6525619855
359PhosphorylationSSGPQTSTTPQVLSP
CCCCCCCCCCCCCCC		45.9725619855
360PhosphorylationSGPQTSTTPQVLSPT
CCCCCCCCCCCCCCC		16.1025619855
365PhosphorylationSTTPQVLSPTITSPP
CCCCCCCCCCCCCCC		22.5727087446
367PhosphorylationTPQVLSPTITSPPNA
CCCCCCCCCCCCCCC		33.2525619855
369PhosphorylationQVLSPTITSPPNALP
CCCCCCCCCCCCCCC		37.3425619855
370PhosphorylationVLSPTITSPPNALPR
CCCCCCCCCCCCCCC		34.2125619855
379PhosphorylationPNALPRRSSRLFTSD
CCCCCCCCCCCCCCC		22.5329899451
380PhosphorylationNALPRRSSRLFTSDS
CCCCCCCCCCCCCCC		31.0629899451
387PhosphorylationSRLFTSDSSTTKENS
CCCCCCCCCCCHHHH		29.3826745281
388PhosphorylationRLFTSDSSTTKENSK
CCCCCCCCCCHHHHH		45.1229514104
389PhosphorylationLFTSDSSTTKENSKK
CCCCCCCCCHHHHHH		45.9326745281
390PhosphorylationFTSDSSTTKENSKKL
CCCCCCCCHHHHHHC		38.0126745281
394PhosphorylationSSTTKENSKKLKMKF
CCCCHHHHHHCCCCC		32.0529514104
395AcetylationSTTKENSKKLKMKFP
CCCHHHHHHCCCCCC		73.957190207
396AcetylationTTKENSKKLKMKFPP
CCHHHHHHCCCCCCC		53.847190213
398AcetylationKENSKKLKMKFPPKI
HHHHHHCCCCCCCCC		49.267190219
412PhosphorylationIPNRKTKSKTNKGGL
CCCCCCCCCCCCCCC		50.3623608596
423PhosphorylationKGGLTQPSINDSLEI
CCCCCCCCHHCCEEE		24.9826643407
427PhosphorylationTQPSINDSLEITKLD
CCCCHHCCEEEEECC		24.3428066266
431PhosphorylationINDSLEITKLDSSII
HHCCEEEEECCCCCC		19.0428066266
435PhosphorylationLEITKLDSSIISEGK
EEEEECCCCCCCCCE		33.6028066266
436PhosphorylationEITKLDSSIISEGKI
EEEECCCCCCCCCEE		24.4928066266
439PhosphorylationKLDSSIISEGKITTV
ECCCCCCCCCEEEEE		38.33-
447PhosphorylationEGKITTVTPQIQAFN
CCEEEEECHHHHHHH		13.8426643407
565UbiquitinationKDLTDMDKNSPEAWC
CCCCCCCCCCHHHHH		53.33-
589UbiquitinationREHDIAIKFFQRAIQ
CHHHHHHHHHHHHHC		30.98-
688UbiquitinationHALKKSEKALDTLNK
HHHHHCHHHHHHCCC		62.43-
695UbiquitinationKALDTLNKAIVIDPK
HHHHHCCCCEEECCC		42.47-
702UbiquitinationKAIVIDPKNPLCKFH
CCEEECCCCCCCHHH		68.40-
707UbiquitinationDPKNPLCKFHRASVL
CCCCCCCHHHHHHHH		52.46-
719UbiquitinationSVLFANEKYKSALQE
HHHHCCHHHHHHHHH		58.76-
721UbiquitinationLFANEKYKSALQELE
HHCCHHHHHHHHHHH		40.08-
731UbiquitinationLQELEELKQIVPKES
HHHHHHHHCCCCHHH		41.06-
738PhosphorylationKQIVPKESLVYFLIG
HCCCCHHHHHHHHHH		29.3025619855
741PhosphorylationVPKESLVYFLIGKVY
CCHHHHHHHHHHHHH		9.6525619855
777UbiquitinationKGANNQIKEAIDKRY
CCCCHHHHHHHHHHC		31.18-
822PhosphorylationTQLHAAESDEF----
CCCHHHHCCCC----		37.40-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDC27_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
427SPhosphorylation

-
447TPhosphorylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDC27_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FZR1_MOUSEFzr1physical
11179223
CDC27_HUMANCDC27physical
20360068
FZR1_MOUSEFzr1physical
15029244
APC7_MOUSEAnapc7physical
10922056
CDC26_MOUSECdc26physical
10922056
FZR1_MOUSEFzr1physical
25913861
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDC27_MOUSE

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Related Literatures of Post-Translational Modification

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