CD7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD7_HUMAN
• UniProt AC: P09564
• Protein Name: T-cell antigen CD7
• Gene Name: CD7
• Organism: Homo sapiens (Human).
• Sequence Length: 240
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Not yet known..
• Protein Sequence: MAGPPRLLLLPLLLALARGLPGALAAQEVQQSPHCTTVPVGASVNITCSTSGGLRGIYLRQLGPQPQDIIYYEDGVVPTTDRRFRGRIDFSGSQDNLTITMHRLQLSDTGTYTCQAITEVNVYGSGTLVLVTEEQSQGWHRCSDAPPRASALPAPPTGSALPDPQTASALPDPPAASALPAALAVISFLLGLGLGVACVLARTQIKKLCSWRDKNSAACVVYEDMSHSRCNTLSSPNQYQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	N-linked_Glycosylation	VPVGASVNITCSTSG ECCCCEEEEEEECCC	22.74	UniProtKB CARBOHYD
96	N-linked_Glycosylation	DFSGSQDNLTITMHR CCCCCCCCEEEEEEE	31.29	19159218
96	N-linked_Glycosylation	DFSGSQDNLTITMHR CCCCCCCCEEEEEEE	31.29	19349973
198	S-palmitoylation	GLGLGVACVLARTQI HHHHHHHHHHHHHHH	2.09	3501369
214	Methylation	KLCSWRDKNSAACVV HHHCCCCCCCEEEEE	44.20	23644510
214	Ubiquitination	KLCSWRDKNSAACVV HHHCCCCCCCEEEEE	44.20	-
215	N-linked_Glycosylation	LCSWRDKNSAACVVY HHCCCCCCCEEEEEE	40.96	-
215	N-linked_Glycosylation	LCSWRDKNSAACVVY HHCCCCCCCEEEEEE	40.96	19349973
216	Phosphorylation	CSWRDKNSAACVVYE HCCCCCCCEEEEEEE	24.00	28796482
222	Phosphorylation	NSAACVVYEDMSHSR CCEEEEEEECCCCCC	5.94	19605366
226	Phosphorylation	CVVYEDMSHSRCNTL EEEEECCCCCCCCCC	30.54	23401153
228	Phosphorylation	VYEDMSHSRCNTLSS EEECCCCCCCCCCCC	31.08	23401153
232	Phosphorylation	MSHSRCNTLSSPNQY CCCCCCCCCCCCCCC	31.48	30576142
234	Phosphorylation	HSRCNTLSSPNQYQ- CCCCCCCCCCCCCC-	41.53	26552605
235	Phosphorylation	SRCNTLSSPNQYQ-- CCCCCCCCCCCCC--	30.86	29978859
239	Phosphorylation	TLSSPNQYQ------ CCCCCCCCC------	23.88	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P85A_HUMAN	PIK3R1	physical	12594831
P4K2A_HUMAN	PI4K2A	physical	12594831
IKBA_HUMAN	NFKBIA	physical	21988832
CPTP_HUMAN	CPTP	physical	21988832
PTH2_HUMAN	PTRH2	physical	28514442
MYADM_HUMAN	MYADM	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00002: Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96, AND MASS SPECTROMETRY.
PubMed: 19349973

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96, AND MASS SPECTROMETRY.
PubMed: 19159218