dbPTM

BUD13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BUD13_MOUSE
UniProt AC	Q8R149
Protein Name	BUD13 homolog
Gene Name	Bud13
Organism	Mus musculus (Mouse).
Sequence Length	637
Subcellular Localization
Protein Description
Protein Sequence	MAAAPPLTKAEYLKRYLSGTDAGLEGGPEAGRKRRKKRPKPGGAGGKGMRIVDDDVGWAAISTAKPEKEEEEDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHGEDGHFHHDDQDSSPPRRVRHDTPDTSPPRKARHDTPDPSPPRKARHDTPDTSPPRKARHDTPDPSPPRKARHDTPDPSPPRRVRHDTPDLSPPRRVRHDTPDLSPPRRVRHDTPDPSPPRRVRHDLDASPPRKSHRNSSAVSPRRGHHGSLGTSSPRQTHNHSPTAAQHRRTLDSSGTQHLRRAHHESPDLELHKAKSSKAAERAPSKAASQSGLGPSHPSLSTNSKYEHDSDLSPPRKRQAKAHFEAKKQLDSKGVYQKASDSDLSPPRKKKNSGHQDSDSDLSPPRNRPRRQSSDSDLSPPRRRQRTKSSDSDLSPPRRSPRPGKKTAHMYSGAKTGLVTDVQREHQELKKQDQDTTDLGAQFEFTETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKNKKVKPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFARLASKKAVEELAYKWSVEDM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAAAPPLTKAEYLKR CCCCCCCCHHHHHHH	33.70	-
16	Phosphorylation	KAEYLKRYLSGTDAG HHHHHHHHHHCCCCC	12.02	28066266
18	Phosphorylation	EYLKRYLSGTDAGLE HHHHHHHHCCCCCCC	30.61	25159016
20	Phosphorylation	LKRYLSGTDAGLEGG HHHHHHCCCCCCCCC	21.21	25159016
121	Phosphorylation	FHHDDQDSSPPRRVR CCCCCCCCCCCCCCC	38.83	27742792
122	Phosphorylation	HHDDQDSSPPRRVRH CCCCCCCCCCCCCCC	47.41	27087446
131	Phosphorylation	PRRVRHDTPDTSPPR CCCCCCCCCCCCCCC	19.55	25521595
134	Phosphorylation	VRHDTPDTSPPRKAR CCCCCCCCCCCCCCC	44.32	25521595
135	Phosphorylation	RHDTPDTSPPRKARH CCCCCCCCCCCCCCC	40.04	27087446
144	Phosphorylation	PRKARHDTPDPSPPR CCCCCCCCCCCCCCC	24.38	27087446
148	Phosphorylation	RHDTPDPSPPRKARH CCCCCCCCCCCCCCC	55.72	27087446
157	Phosphorylation	PRKARHDTPDTSPPR CCCCCCCCCCCCCCC	19.55	25521595
160	Phosphorylation	ARHDTPDTSPPRKAR CCCCCCCCCCCCCCC	44.32	25521595
161	Phosphorylation	RHDTPDTSPPRKARH CCCCCCCCCCCCCCC	40.04	27087446
170	Phosphorylation	PRKARHDTPDPSPPR CCCCCCCCCCCCCCC	24.38	27087446
174	Phosphorylation	RHDTPDPSPPRKARH CCCCCCCCCCCCCCC	55.72	27087446
183	Phosphorylation	PRKARHDTPDPSPPR CCCCCCCCCCCCCCC	24.38	27087446
187	Phosphorylation	RHDTPDPSPPRRVRH CCCCCCCCCCCCCCC	55.72	27087446
196	Phosphorylation	PRRVRHDTPDLSPPR CCCCCCCCCCCCCCC	16.75	27087446
200	Phosphorylation	RHDTPDLSPPRRVRH CCCCCCCCCCCCCCC	39.99	27087446
209	Phosphorylation	PRRVRHDTPDLSPPR CCCCCCCCCCCCCCC	16.75	27087446
213	Phosphorylation	RHDTPDLSPPRRVRH CCCCCCCCCCCCCCC	39.99	27087446
222	Phosphorylation	PRRVRHDTPDPSPPR CCCCCCCCCCCCCCC	24.38	27087446
226	Phosphorylation	RHDTPDPSPPRRVRH CCCCCCCCCCCCCCC	55.72	27087446
238	Phosphorylation	VRHDLDASPPRKSHR CCCCCCCCCCCCCCC	34.79	26824392
247	Phosphorylation	PRKSHRNSSAVSPRR CCCCCCCCCCCCCCC	21.45	23684622
248	Phosphorylation	RKSHRNSSAVSPRRG CCCCCCCCCCCCCCC	35.92	20139300
251	Phosphorylation	HRNSSAVSPRRGHHG CCCCCCCCCCCCCCC	16.65	25521595
259	Phosphorylation	PRRGHHGSLGTSSPR CCCCCCCCCCCCCCC	21.19	27149854
262	Phosphorylation	GHHGSLGTSSPRQTH CCCCCCCCCCCCCCC	31.18	27149854
263	Phosphorylation	HHGSLGTSSPRQTHN CCCCCCCCCCCCCCC	36.22	26824392
264	Phosphorylation	HGSLGTSSPRQTHNH CCCCCCCCCCCCCCC	24.76	26824392
268	Phosphorylation	GTSSPRQTHNHSPTA CCCCCCCCCCCCCCH	26.40	25159016
272	Phosphorylation	PRQTHNHSPTAAQHR CCCCCCCCCCHHHHH	29.30	26824392
274	Phosphorylation	QTHNHSPTAAQHRRT CCCCCCCCHHHHHHH	37.33	25159016
281	Phosphorylation	TAAQHRRTLDSSGTQ CHHHHHHHHCCCHHH	34.57	28066266
284	Phosphorylation	QHRRTLDSSGTQHLR HHHHHHCCCHHHHHH	33.51	-
285	Phosphorylation	HRRTLDSSGTQHLRR HHHHHCCCHHHHHHH	45.59	-
297	Phosphorylation	LRRAHHESPDLELHK HHHHHHCCCCCHHHH	21.25	26824392
320	Phosphorylation	RAPSKAASQSGLGPS HCCHHHHHHCCCCCC	29.73	28066266
322	Phosphorylation	PSKAASQSGLGPSHP CHHHHHHCCCCCCCC	33.23	28066266
327	Phosphorylation	SQSGLGPSHPSLSTN HHCCCCCCCCCCCCC	46.35	26643407
330	Phosphorylation	GLGPSHPSLSTNSKY CCCCCCCCCCCCCCC	29.54	26643407
332	Phosphorylation	GPSHPSLSTNSKYEH CCCCCCCCCCCCCCC	29.85	26643407
333	Phosphorylation	PSHPSLSTNSKYEHD CCCCCCCCCCCCCCC	49.13	26643407
335	Phosphorylation	HPSLSTNSKYEHDSD CCCCCCCCCCCCCCC	36.38	26643407
337	Phosphorylation	SLSTNSKYEHDSDLS CCCCCCCCCCCCCCC	20.51	25619855
341	Phosphorylation	NSKYEHDSDLSPPRK CCCCCCCCCCCCCHH	42.21	27742792
344	Phosphorylation	YEHDSDLSPPRKRQA CCCCCCCCCCHHHHH	37.54	26824392
359	Acetylation	KAHFEAKKQLDSKGV HHHHHHHHHHCCCCC	64.24	15612645
367	Phosphorylation	QLDSKGVYQKASDSD HHCCCCCCCCCCCCC	16.99	25159016
371	Phosphorylation	KGVYQKASDSDLSPP CCCCCCCCCCCCCCC	44.69	21082442
373	Phosphorylation	VYQKASDSDLSPPRK CCCCCCCCCCCCCCC	37.65	21082442
376	Phosphorylation	KASDSDLSPPRKKKN CCCCCCCCCCCCCCC	37.54	26824392
384	Phosphorylation	PPRKKKNSGHQDSDS CCCCCCCCCCCCCCC	46.67	21149613
389	Phosphorylation	KNSGHQDSDSDLSPP CCCCCCCCCCCCCCC	32.23	27087446
391	Phosphorylation	SGHQDSDSDLSPPRN CCCCCCCCCCCCCCC	44.39	27087446
394	Phosphorylation	QDSDSDLSPPRNRPR CCCCCCCCCCCCCCC	37.54	27087446
404	Phosphorylation	RNRPRRQSSDSDLSP CCCCCCCCCCCCCCC	34.01	25159016
405	Phosphorylation	NRPRRQSSDSDLSPP CCCCCCCCCCCCCCC	32.56	25159016
407	Phosphorylation	PRRQSSDSDLSPPRR CCCCCCCCCCCCCHH	42.26	25159016
410	Phosphorylation	QSSDSDLSPPRRRQR CCCCCCCCCCHHHHC	37.54	25159016
426	Phosphorylation	KSSDSDLSPPRRSPR CCCCCCCCCCCCCCC	37.54	23384938
512	Phosphorylation	DSERDELYAQWGKGL HHHHHHHHHHHHHHH	8.49	-
517	Acetylation	ELYAQWGKGLAQSRQ HHHHHHHHHHHHHHH	48.03	22826441
573	Acetylation	FIKKNKAKENKNKKV HHHHHHHHHCCCCCC	64.53	6568795
584	Phosphorylation	NKKVKPRYSGPAPPP CCCCCCCCCCCCCCC	26.89	28066266
585	Phosphorylation	KKVKPRYSGPAPPPN CCCCCCCCCCCCCCC	39.31	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BUD13_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BUD13_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BUD13_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DX39A_HUMAN	DDX39A	physical	20360068
PIP_HUMAN	PIP	physical	20360068
RBMX2_HUMAN	RBMX2	physical	20360068
KIN17_HUMAN	KIN	physical	20360068
GPKOW_HUMAN	GPKOW	physical	20360068
DHX16_HUMAN	DHX16	physical	20360068
CWC22_HUMAN	CWC22	physical	20360068
BUD13_HUMAN	BUD13	physical	20360068
DX39B_HUMAN	DDX39B	physical	20360068
SRSF1_HUMAN	SRSF1	physical	20360068

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BUD13_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-157; THR-170; SER-174;THR-209; SER-213; THR-222 AND SER-226, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341; SER-344; SER-371;SER-373 AND SER-376, AND MASS SPECTROMETRY.	17242355 [Abstract]