ARL11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARL11_HUMAN
• UniProt AC: Q969Q4
• Protein Name: ADP-ribosylation factor-like protein 11
• Gene Name: ARL11
• Organism: Homo sapiens (Human).
• Sequence Length: 196
• Protein Description: May play a role in apoptosis. May act as a tumor suppressor..
• Protein Sequence: MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGHVSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVPFLVLANKQEAPDALPLLKIRNRLSLERFQDHCWELRGCSALTGEGLPEALQSLWSLLKSRSCMCLQARAHGAERGDSKRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSVNSRGH ------CCCCCCCCC	40.06	-
6	Phosphorylation	--MGSVNSRGHKAEA --CCCCCCCCCHHHE	37.17	18187866
22	Phosphorylation	VVMMGLDSAGKTTLL EEEEECCCCCCEEEE	43.92	26074081
25	Ubiquitination	MGLDSAGKTTLLYKL EECCCCCCEEEEEEE	37.74	23000965
26	Phosphorylation	GLDSAGKTTLLYKLK ECCCCCCEEEEEEEC	23.04	26074081
27	Phosphorylation	LDSAGKTTLLYKLKG CCCCCCEEEEEEECC	20.46	26074081
30	Phosphorylation	AGKTTLLYKLKGHQL CCCEEEEEEECCCCC	19.86	28152594
31	Ubiquitination	GKTTLLYKLKGHQLV CCEEEEEEECCCCCE	43.63	23000965
31	Acetylation	GKTTLLYKLKGHQLV CCEEEEEEECCCCCE	43.63	23236377
31	2-Hydroxyisobutyrylation	GKTTLLYKLKGHQLV CCEEEEEEECCCCCE	43.63	-
31	Malonylation	GKTTLLYKLKGHQLV CCEEEEEEECCCCCE	43.63	26320211
33	Ubiquitination	TTLLYKLKGHQLVET EEEEEEECCCCCEEE	50.63	23000965
40	Phosphorylation	KGHQLVETLPTVGFN CCCCCEEECCCCCEE	30.47	26074081
73	Phosphorylation	GQAPLRASWKDYLEG CCCCCCCCHHHHHCC	28.38	24719451
134	Ubiquitination	PDALPLLKIRNRLSL CCHHHHHHHHHCCCH	47.50	-
171	Phosphorylation	EALQSLWSLLKSRSC HHHHHHHHHHHHCCC	29.17	24719451
175	Phosphorylation	SLWSLLKSRSCMCLQ HHHHHHHHCCCHHHH	29.42	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARL11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARL11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARL11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCH2_HUMAN	TRIP13	physical	19060904
SESD1_HUMAN	SESTD1	physical	28514442
MTMR8_HUMAN	MTMR8	physical	28514442
SENP1_HUMAN	SENP1	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 151400: Leukemia, chronic lymphocytic (CLL)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND MASSSPECTROMETRY.
PubMed: 18187866