dbPTM

ARG35_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARG35_HUMAN
UniProt AC	A5YM69
Protein Name	Rho guanine nucleotide exchange factor 35
Gene Name	ARHGEF35
Organism	Homo sapiens (Human).
Sequence Length	484
Subcellular Localization
Protein Description
Protein Sequence	MEAEEAQHGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQQSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAGRQARTLAPPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQTRYYSPCEEHPAETNQNEGAESGTIRQGEELPSEELQESQGLLHPQEVQVLEEQGQQEAGFRGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGLNDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQEDHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCDLFPGASYLVTQIPGTQTESRAEELSPAALSPLLEPIRCSHQPISLLGSFLTEESPDKEKLLSVL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	EEAQHGASPPISAIE HHHHCCCCCCCHHHH	35.48	29255136
15	Phosphorylation	HGASPPISAIEEFSI CCCCCCCHHHHEEEC	29.03	29255136
21	Phosphorylation	ISAIEEFSIIPEAPM CHHHHEEECCCCCCC	23.92	23663014
30	Phosphorylation	IPEAPMRSSQVSALG CCCCCCCCCCCHHHC	20.90	27251275
31	Phosphorylation	PEAPMRSSQVSALGL CCCCCCCCCCHHHCC	25.00	27251275
34	Phosphorylation	PMRSSQVSALGLEAQ CCCCCCCHHHCCCCC	15.33	27251275
57	Phosphorylation	WREEHRLSATQQSEL HHHHHCCCHHHHHHH	29.27	29255136
59	Phosphorylation	EEHRLSATQQSELRD HHHCCCHHHHHHHHH	24.62	29255136
62	Phosphorylation	RLSATQQSELRDVCD CCCHHHHHHHHHHHH	28.87	20068231
70	Phosphorylation	ELRDVCDYAIETMPS HHHHHHHHHHHHCCC	12.35	25106551
74	Phosphorylation	VCDYAIETMPSFPKE HHHHHHHHCCCCCCC	28.41	27251275
77	Phosphorylation	YAIETMPSFPKEGSA HHHHHCCCCCCCCCC	43.27	28348404
92	Phosphorylation	DVEPNQESLVAEACD CCCCCHHHHHHHHCC	20.55	26657352
100	Phosphorylation	LVAEACDTPEHWEAV HHHHHCCCHHHHHHC	30.38	29496963
145	Phosphorylation	PFSSDLGSEEEEVEF CCCCCCCCCHHHCCC	49.48	22468782
182	Phosphorylation	DNSGQTRYYSPCEEH CCCCCEEEECCCCCC	16.22	29255136
183	Phosphorylation	NSGQTRYYSPCEEHP CCCCEEEECCCCCCC	11.66	23663014
184	Phosphorylation	SGQTRYYSPCEEHPA CCCEEEECCCCCCCC	17.72	23401153
193	Phosphorylation	CEEHPAETNQNEGAE CCCCCCCCCCCCCCC	44.18	23663014
201	Phosphorylation	NQNEGAESGTIRQGE CCCCCCCCCCCCCCC	40.48	23927012
203	Phosphorylation	NEGAESGTIRQGEEL CCCCCCCCCCCCCCC	23.43	23927012
212	Phosphorylation	RQGEELPSEELQESQ CCCCCCCHHHHHHHC	57.22	28348404
218	Phosphorylation	PSEELQESQGLLHPQ CHHHHHHHCCCCCHH	19.31	28348404
294	Phosphorylation	QGERMGLTGEPEGLN CCCCCCCCCCCCCCC	33.50	26074081
340	Phosphorylation	PEENRADSQDEKSQT CHHHCCCCCCHHHHH	38.25	26657352
381	Phosphorylation	QEAKEPESWDGGRLG CCCCCCCCCCCCCCC	40.98	24719451
395	Phosphorylation	GAVGRARSREEENEH CHHHCCCCHHHHHCC	42.96	27251275
406	Phosphorylation	ENEHHGPSMPALIAP HHCCCCCCCCCEECC	41.83	28348404
445	Phosphorylation	ESRAEELSPAALSPL HHHHHHCCHHHHHHH	18.77	29255136
450	Phosphorylation	ELSPAALSPLLEPIR HCCHHHHHHHHHCCC	14.58	28355574
459	Phosphorylation	LLEPIRCSHQPISLL HHHCCCCCCCCHHHH	18.46	23312004
464	Phosphorylation	RCSHQPISLLGSFLT CCCCCCHHHHHHHHC	24.99	28102081
468	Phosphorylation	QPISLLGSFLTEESP CCHHHHHHHHCCCCC	19.63	25159151
471	Phosphorylation	SLLGSFLTEESPDKE HHHHHHHCCCCCCHH	35.38	22199227
474	Phosphorylation	GSFLTEESPDKEKLL HHHHCCCCCCHHHHH	31.97	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARG35_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARG35_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARG35_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARHG5_HUMAN	ARHGEF5	physical	28514442
HEM2_HUMAN	ALAD	physical	28514442
OBSL1_HUMAN	OBSL1	physical	28514442
TYSY_HUMAN	TYMS	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARG35_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-182, AND MASSSPECTROMETRY.	17389395 [Abstract]