AP5M1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP5M1_HUMAN
• UniProt AC: Q9H0R1
• Protein Name: AP-5 complex subunit mu-1
• Gene Name: AP5M1
• Organism: Homo sapiens (Human).
• Sequence Length: 490
• Subcellular Localization: Cytoplasm, cytosol . Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . May cycle on and off membranes.
• Protein Description: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death..
• Protein Sequence: MAQRAVWLISHEPGTPLCGTVRFSRRYPTVEKRARVFNGASYVPVPEDGPFLKALLFELRLLDDDKDFVESRDSCSRINKTSIYGLLIGGEELWPVVAFLKNDMIYACVPLVEQTLSPRPPLISVSGVSQGFEFLFGIQDFLYSGQKNDSELNTKLSQLPDLLLQACPFGTLLDANLQNSLDNTNFASVTQPQKQPAWKTGTYKGKPQVSISITEKVKSMQYDKQGIADTWQVVGTVTCKCDLEGIMPNVTISLSLPTNGSPLQDILVHPCVTSLDSAILTSSSIDAMDDSAFSGPYKFPFTPPLESFNLCFYTSQVPVPPILGFYQMKEEEVQLRITINLKLHESVKNNFEFCEAHIPFYNRGPITHLEYKTSFGQLEVFREKSLLIWIIGQKFPKSMEISLSGTVTFGAKSHEKQPFDPICTGETAYLKLHFRILDYTLTGCYADQHSVQVFASGKPKISAHRKLISSDYYIWNSKAPAPVTYGSLLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	LCGTVRFSRRYPTVE CCCEEEECCCCCCHH	12.80	23911959
27	Phosphorylation	TVRFSRRYPTVEKRA EEEECCCCCCHHHHE	11.35	28152594
29	Phosphorylation	RFSRRYPTVEKRARV EECCCCCCHHHHEEE	32.15	28152594
32	Ubiquitination	RRYPTVEKRARVFNG CCCCCHHHHEEEECC	47.20	-
53	Ubiquitination	PEDGPFLKALLFELR CCCCHHHHHHHHHEE	37.05	-
66	Ubiquitination	LRLLDDDKDFVESRD EECCCCCHHHHHCCC	61.12	-
194	Ubiquitination	ASVTQPQKQPAWKTG CCCCCCCCCCCCCCC	66.00	-
199	Ubiquitination	PQKQPAWKTGTYKGK CCCCCCCCCCCCCCC	38.90	-
203	Phosphorylation	PAWKTGTYKGKPQVS CCCCCCCCCCCCCEE	21.06	-
204	Ubiquitination	AWKTGTYKGKPQVSI CCCCCCCCCCCCEEE	61.36	-
206	Ubiquitination	KTGTYKGKPQVSISI CCCCCCCCCCEEEEE	28.29	-
210	Phosphorylation	YKGKPQVSISITEKV CCCCCCEEEEEEHHH	12.84	21406692
212	Phosphorylation	GKPQVSISITEKVKS CCCCEEEEEEHHHHH	18.89	21406692
214	Phosphorylation	PQVSISITEKVKSMQ CCEEEEEEHHHHHCC	23.98	21406692
219	Phosphorylation	SITEKVKSMQYDKQG EEEHHHHHCCCCCCC	17.69	21406692
222	Phosphorylation	EKVKSMQYDKQGIAD HHHHHCCCCCCCCCC	19.23	21406692
224	Ubiquitination	VKSMQYDKQGIADTW HHHCCCCCCCCCCCE	45.55	-
302	Phosphorylation	GPYKFPFTPPLESFN CCCCCCCCCCHHHCE	25.00	25002506
307	Phosphorylation	PFTPPLESFNLCFYT CCCCCHHHCEEEEEE	27.41	25002506
313	Phosphorylation	ESFNLCFYTSQVPVP HHCEEEEEECCCCCC	12.41	25002506
314	Phosphorylation	SFNLCFYTSQVPVPP HCEEEEEECCCCCCC	7.76	25002506
315	Phosphorylation	FNLCFYTSQVPVPPI CEEEEEECCCCCCCC	20.15	25002506
326	Phosphorylation	VPPILGFYQMKEEEV CCCCEEEEECCCEEE	13.10	25002506
398	Phosphorylation	IGQKFPKSMEISLSG ECCCCCCCEEEEEEE	23.14	-
408	Phosphorylation	ISLSGTVTFGAKSHE EEEEEEEEECCCCCC	19.05	-
416	Ubiquitination	FGAKSHEKQPFDPIC ECCCCCCCCCCCCCC	58.82	-
466	Ubiquitination	PKISAHRKLISSDYY CCCCHHHEHHCCCEE	40.06	-
469	Phosphorylation	SAHRKLISSDYYIWN CHHHEHHCCCEEEEC	27.82	21406692
470	Phosphorylation	AHRKLISSDYYIWNS HHHEHHCCCEEEECC	23.73	21406692
472	Phosphorylation	RKLISSDYYIWNSKA HEHHCCCEEEECCCC	9.98	21406692
473	Phosphorylation	KLISSDYYIWNSKAP EHHCCCEEEECCCCC	12.40	21406692
477	Phosphorylation	SDYYIWNSKAPAPVT CCEEEECCCCCCCCC	18.39	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP5M1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP5M1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP5M1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCAF4_HUMAN	DCAF4	physical	26186194
TF3C3_HUMAN	GTF3C3	physical	26186194
SPTCS_HUMAN	SPG11	physical	26186194
AP5B1_HUMAN	AP5B1	physical	26186194
AP5B1_HUMAN	AP5B1	physical	28514442
DCAF4_HUMAN	DCAF4	physical	28514442
SPTCS_HUMAN	SPG11	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.