AMRA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AMRA1_MOUSE
• UniProt AC: A2AH22
• Protein Name: Activating molecule in BECN1-regulated autophagy protein 1
• Gene Name: Ambra1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1300
• Subcellular Localization: Cytoplasmic vesicle, autophagosome . Localizes also to discrete punctae along the ciliary axoneme.
• Protein Description: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation..
• Protein Sequence: MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLSETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGAASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLPSEPGQLAERALSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDGSNRGEAAGPSGEPQNR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	KRVELPDSPRSTFLL EEEECCCCCCCEEEE	21.92	54886857
175	Ubiquitination	REPFAVVKTASEMER CCCEEEEECHHHHCE	31.60	22790023
329	Phosphorylation	SLLPHQDSVPPASAR CCCCCCCCCCCCCCC	29.92	-
395	Phosphorylation	SLGPTRRSLGGPLSS CCCCCCCCCCCCCCC	28.24	28066266
444	Phosphorylation	PPPRTSASSVSLLSV CCCCCCHHHHHHHHH	30.92	-
636	Phosphorylation	SSSRLELSSSASSQE CCCCEEECCCCCCCH	16.93	30635358
637	Phosphorylation	SSRLELSSSASSQEE CCCEEECCCCCCCHH	42.41	30635358
638	Phosphorylation	SRLELSSSASSQEER CCEEECCCCCCCHHH	28.88	30635358
640	Phosphorylation	LELSSSASSQEERTV EEECCCCCCCHHHEE	34.21	30635358
641	Phosphorylation	ELSSSASSQEERTVG EECCCCCCCHHHEEE	41.13	30635358
723	Phosphorylation	YPDPARLSPAAYYAQ CCCHHHCCHHHHHHH	13.62	25266776
748	Methylation	SIRQRSMRYQQNRLR HHHHHHHHHHHHHHH	27.62	24129315
748	Asymmetric dimethylarginine	SIRQRSMRYQQNRLR HHHHHHHHHHHHHHH	27.62	-
787	Phosphorylation	FEDNGDRSRHRAPRN CCCCCCCCCCCCCCC	36.86	30165576
798	Phosphorylation	APRNARMSAPSLGRF CCCCCCCCCHHHCCC	31.32	62172039
1192	Phosphorylation	VSHRIHRSSQTGTES EEEEEEECCCCCCCC	16.79	25338131
1193	Phosphorylation	SHRIHRSSQTGTESG EEEEEECCCCCCCCC	31.55	25338131
1204	Phosphorylation	TESGAARTSSPQPST CCCCCCCCCCCCCCC	28.91	23140645
1205	Phosphorylation	ESGAARTSSPQPSTS CCCCCCCCCCCCCCC	34.17	23140645
1206	Phosphorylation	SGAARTSSPQPSTSR CCCCCCCCCCCCCCC	27.26	30352176
1228	Phosphorylation	QLAERALSPRTASWD HHHHHHHCCCCCCCC	16.02	22942356
1233	Phosphorylation	ALSPRTASWDQPSTS HHCCCCCCCCCCCCC	30.49	25338131
1251	Phosphorylation	LPQPALSSSSPVPIP CCCCCCCCCCCCCCC	35.37	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AMRA1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AMRA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AMRA1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRKN_MOUSE	Park2	physical	21753002
DDA1_HUMAN	DDA1	physical	26496610
SPRY4_HUMAN	SPRYD4	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.