AMPO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AMPO_HUMAN
• UniProt AC: Q8N6M6
• Protein Name: Aminopeptidase O
• Gene Name: AOPEP
• Organism: Homo sapiens (Human).
• Sequence Length: 819
• Subcellular Localization: Cytoplasm .
• Protein Description: Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart..
• Protein Sequence: MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTFSSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVSEEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVYTVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLATERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPSLGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQDEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKLLPDQLVLLLEHLLEQKTLSPRTLQSLQRTYHLQDQDAEVRHRWCELIVKHKFTKAYKSVERFLQEDQAMGVYLYGELMVSEDARQQQLARRCFERTKEQMDRSSAQVVAEMLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	DLDVDFESQVIEGTI EECCCCCCCEEEEEE	29.73	-
55	Ubiquitination	EDGNRFKKQNSSIEE ECCCHHHHCCCCHHH	52.58	-
58	Phosphorylation	NRFKKQNSSIEEACQ CHHHHCCCCHHHHHH	30.14	-
59	Phosphorylation	RFKKQNSSIEEACQS HHHHCCCCHHHHHHC	41.38	-
89	Phosphorylation	IPVTNARTFSSEMEY CCCCCCCCCCCCCCC	26.01	29052541
91	Phosphorylation	VTNARTFSSEMEYND CCCCCCCCCCCCCCC	25.44	29052541
92	Phosphorylation	TNARTFSSEMEYNDF CCCCCCCCCCCCCCE	36.45	29052541
96	Phosphorylation	TFSSEMEYNDFAICS CCCCCCCCCCEEEEE	20.79	29052541
103	Phosphorylation	YNDFAICSKGEKDTS CCCEEEEECCCCCCC	37.27	29052541
123	Phosphorylation	HDNQEHASGISSSKY CCCCHHHCCCCCCCE	38.27	-
126	Phosphorylation	QEHASGISSSKYCCD CHHHCCCCCCCEECC	31.89	-
127	Phosphorylation	EHASGISSSKYCCDT HHHCCCCCCCEECCC	29.00	-
128	Phosphorylation	HASGISSSKYCCDTG HHCCCCCCCEECCCC	22.36	-
169	Ubiquitination	AAVPGLEKFTRSPEL EECCCHHHHCCCCCC	58.01	-
193	Phosphorylation	QIVRELVTLPANRWR HHHHHHHCCCCHHHH	39.38	20860994
231	Ubiquitination	TWSLQIRKTGAQTAT CEEEEEHHHCCCCCC	53.60	-
232	Phosphorylation	WSLQIRKTGAQTATD EEEEEHHHCCCCCCC	28.09	24719451
250	Phosphorylation	AIRIWYKTKPEGRSV EEEEEEECCCCCCCC	35.81	24719451
256	Phosphorylation	KTKPEGRSVTWTSDQ ECCCCCCCCEEECCC	34.45	29083192
258	Phosphorylation	KPEGRSVTWTSDQSG CCCCCCCEEECCCCC	25.03	29083192
261	Phosphorylation	GRSVTWTSDQSGRPC CCCCEEECCCCCCCE	25.80	-
473	Ubiquitination	LTGGNHLCGTRLCHE HCCCCCCCCHHHHHH	3.99	29967540
572	Ubiquitination	DSGASVIKHGLNPEK CCCCCHHHCCCCHHH	29.48	29967540
586	Phosphorylation	KIFMQVHYLKGYFLL HHHHHHHHHHHHHHH	15.97	-
605	Phosphorylation	KRLGDETYFSFLRKF HHHCCHHHHHHHHHH	8.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AMPO_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AMPO_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AMPO_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUN2_HUMAN	SUN2	physical	22632968
LRC40_HUMAN	LRRC40	physical	28514442
ZDH17_HUMAN	ZDHHC17	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
SUZ12_HUMAN	SUZ12	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.