AGTRA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGTRA_RAT
• UniProt AC: P25095
• Protein Name: Type-1A angiotensin II receptor
• Gene Name: Agtr1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 359
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system..
• Protein Sequence: MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	N-linked_Glycosylation	----MALNSSAEDGI ----CCCCCCHHHHH	25.12	-
176	N-linked_Glycosylation	VYFIENTNITVCAFH EEEEECCCEEEEEEE	39.24	-
188	N-linked_Glycosylation	AFHYESRNSTLPIGL EEEECCCCCCCCCCC	48.93	-
319	Phosphorylation	YFLQLLKYIPPKAKS HHHHHHHHCCCCCCC	20.73	22817900
331	Phosphorylation	AKSHSSLSTKMSTLS CCCCCCCCCCCCCCC	28.12	16831865
332	Phosphorylation	KSHSSLSTKMSTLSY CCCCCCCCCCCCCCC	35.74	-
335	Phosphorylation	SSLSTKMSTLSYRPS CCCCCCCCCCCCCCC	27.96	30181290
336	Phosphorylation	SLSTKMSTLSYRPSD CCCCCCCCCCCCCCC	19.07	30181290
338	Phosphorylation	STKMSTLSYRPSDNM CCCCCCCCCCCCCCC	21.13	16831865
339	Phosphorylation	TKMSTLSYRPSDNMS CCCCCCCCCCCCCCC	29.65	22673903
342	Phosphorylation	STLSYRPSDNMSSSA CCCCCCCCCCCCCCC	32.39	22673903
346	Phosphorylation	YRPSDNMSSSAKKPA CCCCCCCCCCCCCCC	27.65	22673903
347	Phosphorylation	RPSDNMSSSAKKPAS CCCCCCCCCCCCCCC	24.44	22673903
348	Phosphorylation	PSDNMSSSAKKPASC CCCCCCCCCCCCCCC	36.48	16831865
354	Phosphorylation	SSAKKPASCFEVE-- CCCCCCCCCCCCC--	28.06	30181290
355	S-palmitoylation	SAKKPASCFEVE--- CCCCCCCCCCCC---	3.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
331	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
338	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
348	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGTRA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGTRA_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRPV4_RAT	Trpv4	physical	20650893
GNAQ_HUMAN	GNAQ	physical	17498700
ARRB1_HUMAN	ARRB1	physical	17498700
ANGT_RAT	Agt	physical	7622467
DRD1_RAT	Drd1	physical	22193384

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.