TRPV4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRPV4_RAT
• UniProt AC: Q9ERZ8
• Protein Name: Transient receptor potential cation channel subfamily V member 4
• Gene Name: Trpv4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 871
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein . Cell junction, adherens junction . Cell projection, cilium . Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum.
• Protein Description: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. [PubMed: 11081638 Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification]
• Protein Sequence: MADPGDGPRAAPGDVAEPPGDESGTSGGEAFPLSSLANLFEGEEGSSSLSPVDASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLSYLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLLTGVLFFFTSIKDLFMKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCNEDQSNCTVPSYPACRDSETFSAFLLDLFKLTIGMGDLEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKSEIYQYYGFSHTMGRLRRDRWSSVVPRVVELNKNSGTDEVVVPLDNLGNPNCDGHQQGYAPKWRAEDAPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
91	Phosphorylation	DLLESTLYESSVVPG HHHHHHHHHCCCCCC	17.54	21940666
110	Phosphorylation	PMDSLFDYGTYRHHP CCHHHCCCCCCCCCC	12.20	21940666
253	Phosphorylation	IERRCKHYVELLVAQ HHHHCHHHHHHHHHC	4.90	-
663	Phosphorylation	SYPACRDSETFSAFL CCCCCCCCHHHHHHH	21.13	25575281
665	Phosphorylation	PACRDSETFSAFLLD CCCCCCHHHHHHHHH	27.17	25575281
667	Phosphorylation	CRDSETFSAFLLDLF CCCCHHHHHHHHHHH	26.07	25575281
805	Phosphorylation	DPGKSEIYQYYGFSH CCCCCHHHHHHCCCC	6.09	-
824	Phosphorylation	LRRDRWSSVVPRVVE CCHHCHHHCCCEEEE	21.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRPV4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRPV4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRPV4_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARRB1_RAT	Arrb1	physical	20650893
AGTRA_RAT	Agtr1a	physical	20650893

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.