DRD1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRD1_RAT
• UniProt AC: P18901
• Protein Name: D(1A) dopamine receptor
• Gene Name: Drd1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 446
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.
• Protein Description: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase..
• Protein Sequence: MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	N-linked_Glycosylation	----MAPNTSTMDEA ----CCCCCCCCCCC	36.80	-
256	Phosphorylation	NPVECAQSESSFKMS CCCHHHCCCCCCCCC	22.41	22817900
258	Phosphorylation	VECAQSESSFKMSFK CHHHCCCCCCCCCCH	46.45	22817900
259	Phosphorylation	ECAQSESSFKMSFKR HHHCCCCCCCCCCHH	25.49	22817900
268	Phosphorylation	KMSFKRETKVLKTLS CCCCHHHHHHHHHHH	30.41	22817900
347	S-palmitoylation	AFSTLLGCYRLCPTT HHHHHHHHHHHCCCC	1.48	-
351	S-palmitoylation	LLGCYRLCPTTNNAI HHHHHHHCCCCCCCE	1.76	-
398	Phosphorylation	IPHAVGSSEDLKKEE ECCCCCCCHHHHHHH	29.24	30411139
421	Phosphorylation	EKLSPALSVILDYDT HHHCHHHHHHCCCCC	14.82	-
428	Phosphorylation	SVILDYDTDVSLEKI HHHCCCCCCCCHHHC	31.88	22817900
431	Phosphorylation	LDYDTDVSLEKIQPV CCCCCCCCHHHCCCC	33.35	22817900
439	Phosphorylation	LEKIQPVTHSGQHST HHHCCCCCCCCCCCC	19.60	27097102
441	Phosphorylation	KIQPVTHSGQHST-- HCCCCCCCCCCCC--	30.68	27097102
445	Phosphorylation	VTHSGQHST------ CCCCCCCCC------	28.11	27097102
446	Phosphorylation	THSGQHST------- CCCCCCCC-------	40.27	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
421	S	Phosphorylation	Kinase	PRKD1	Q15139	PSP
428	T	Phosphorylation	Kinase	GRK4	P32298	PSP
431	S	Phosphorylation	Kinase	GRK4	P32298	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DRD1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRD1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NMDZ1_RAT	Grin1	physical	12408866
NMDE1_RAT	Grin2a	physical	12408866
AGTRA_RAT	Agtr1a	physical	22193384

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.