DRD1_RAT - dbPTM
DRD1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DRD1_RAT
UniProt AC P18901
Protein Name D(1A) dopamine receptor
Gene Name Drd1
Organism Rattus norvegicus (Rat).
Sequence Length 446
Subcellular Localization Cell membrane
Multi-pass membrane protein . Endoplasmic reticulum membrane
Multi-pass membrane protein . Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.
Protein Description Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase..
Protein Sequence MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
4N-linked_Glycosylation----MAPNTSTMDEA
----CCCCCCCCCCC
36.80-
256PhosphorylationNPVECAQSESSFKMS
CCCHHHCCCCCCCCC
22.4122817900
258PhosphorylationVECAQSESSFKMSFK
CHHHCCCCCCCCCCH
46.4522817900
259PhosphorylationECAQSESSFKMSFKR
HHHCCCCCCCCCCHH
25.4922817900
268PhosphorylationKMSFKRETKVLKTLS
CCCCHHHHHHHHHHH
30.4122817900
347S-palmitoylationAFSTLLGCYRLCPTT
HHHHHHHHHHHCCCC
1.48-
351S-palmitoylationLLGCYRLCPTTNNAI
HHHHHHHCCCCCCCE
1.76-
398PhosphorylationIPHAVGSSEDLKKEE
ECCCCCCCHHHHHHH
29.2430411139
421PhosphorylationEKLSPALSVILDYDT
HHHCHHHHHHCCCCC
14.82-
428PhosphorylationSVILDYDTDVSLEKI
HHHCCCCCCCCHHHC
31.8822817900
431PhosphorylationLDYDTDVSLEKIQPV
CCCCCCCCHHHCCCC
33.3522817900
439PhosphorylationLEKIQPVTHSGQHST
HHHCCCCCCCCCCCC
19.6027097102
441PhosphorylationKIQPVTHSGQHST--
HCCCCCCCCCCCC--
30.6827097102
445PhosphorylationVTHSGQHST------
CCCCCCCCC------
28.1127097102
446PhosphorylationTHSGQHST-------
CCCCCCCC-------
40.2727097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
421SPhosphorylationKinasePRKD1Q15139
PSP
428TPhosphorylationKinaseGRK4P32298
PSP
431SPhosphorylationKinaseGRK4P32298
PSP

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DRD1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DRD1_RAT !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NMDZ1_RATGrin1physical
12408866
NMDE1_RATGrin2aphysical
12408866
AGTRA_RATAgtr1aphysical
22193384

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DRD1_RAT

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Related Literatures of Post-Translational Modification

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