ZNRF3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNRF3_MOUSE
• UniProt AC: Q5SSZ7
• Protein Name: E3 ubiquitin-protein ligase ZNRF3
• Gene Name: Znrf3
• Organism: Mus musculus (Mouse).
• Sequence Length: 913
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone..
• Protein Sequence: MRPRSGGRPGAPGRRRRRLRRGPRGRRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTHTTGLTGRFSRAGAMLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHLPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSGSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPGAVCVETSNLTRGRQPRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQNLYSPQTPTYVRGYPPLHLDHTLAPHRCSLEHRAYSPAHPFRRPKFSSRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQTIPSVTPRGQSRAFPPSGASSLLFPTMVHVAPPTHVESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSNSSGQCRCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRGPAVHLEGSPPPEELPAGHSQSAGRGEPWLGPASPSGDQLSTCSLEMNYSSNSSLEPRGPNSSTSEVGLEVSPGAALDLRRTWKGGPEGPSCACCFEPQPFPPGSGIETSAGGSSLFLGPRLLEDCNPPSGEPQLGSSQGLYGLHSDHYPRTDGVKYEGLPCCFYEEKQVAHSAGRGNGCYTEDYSVSVQYTLTEEPPPSCYAGPRDLSQRIPIIPEDVDCDLGLPQDCHGMHNHSPWGGALSLDVPRLHWSLGTTREEEQAPCYQAEVQPGCSPEEAGASRASLSSAPQDTQESHALAAEASGPGSGPGIGTGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Methylation	RRLRRGPRGRRLPPP CCCCCCCCCCCCCCC	54.82	30989921
26	Methylation	LRRGPRGRRLPPPPP CCCCCCCCCCCCCCC	37.94	30989927
79	Phosphorylation	TTHTTGLTGRFSRAG CCCCCCCCCCCCCCC	27.88	-
139	Acetylation	PCLTVLGKAKRAVQR CCEEHHHHHHHHHHC	46.72	7385635
405	Phosphorylation	RHGEQNLYSPQTPTY CCCCCCCCCCCCCCE	26.34	26032504
437	Phosphorylation	CSLEHRAYSPAHPFR CCCCCCCCCCCCCCC	18.36	28066266
438	Phosphorylation	SLEHRAYSPAHPFRR CCCCCCCCCCCCCCC	18.02	28066266
590	Phosphorylation	RSSLSSDYDPFIYRS HHHCCCCCCCCCCCC	27.71	26032504
755	Phosphorylation	PRTDGVKYEGLPCCF CCCCCCCCCCCCEEE	16.90	26032504

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZNRF3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNRF3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNRF3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RSPO2_MOUSE	Rspo2	physical	24225776
RSPO2_XENLA	rspo2	physical	24225776
ZNRF3_MOUSE	Znrf3	physical	24349440
RSPO1_HUMAN	RSPO1	physical	24349440

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.