ZN461_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN461_HUMAN
• UniProt AC: Q8TAF7
• Protein Name: Zinc finger protein 461
• Gene Name: ZNF461
• Organism: Homo sapiens (Human).
• Sequence Length: 563
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAHELVMFRDVAIDVSQEEWECLNPAQRNLYKEVMLENYSNLVSLGLSVSKPAVISSLEQGKEPWMVVREETGRWCPGTWKTWGFHNNFLDNNEATDINADLASRDEPQKLSPKRDIYETELSQWVNMEEFKSHSPERSIFSAIWEGNCHFEQHQGQEEGYFRQLMINHENMPIFSQHTLLTQEFYDREKISECKKCRKIFSYHLFFSHHKRTHSKELSECKECTEIVNTPCLFKQQTIQNGDKCNECKECWKAFVHCSQLKHLRIHNGEKRYECNECGKAFNYGSELTLHQRIHTGEKPYECKECGKAFRQRSQLTQHQRLHTGEKPYECKQCGKAFIRGFQLTEHLRLHTGEKPYECKECGKTFRHRSHLTIHQRIHTGEKPYECRECGKAFSYHSSFSHHQKIHSGKKPYECHECGKAFCDGLQLTLHQRIHTGEKPYECKECGKTFRQCSHLKRHQRIHTGEKPHECMICGKAFRLHSHLIQHQRIHTGEKPYECKECGKAFSYHSSFSHHQRIHSGKKPYQCGKAFNHRLQLNLHQTLHTGEKPVRFPLLPPHPSLAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	KEVMLENYSNLVSLG HHHHHHCHHCHHHHC	6.91	-
48	Phosphorylation	NLVSLGLSVSKPAVI CHHHHCCCCCCCCHH	23.65	24719451
50	Phosphorylation	VSLGLSVSKPAVISS HHHCCCCCCCCHHHH	29.55	24850871
112	Phosphorylation	RDEPQKLSPKRDIYE CCCCCCCCCCCCCCH	35.10	23312004
202	Phosphorylation	KKCRKIFSYHLFFSH HHHHHHHHHHHHHCC	18.34	26074081
203	Phosphorylation	KCRKIFSYHLFFSHH HHHHHHHHHHHHCCC	7.56	26074081
208	Phosphorylation	FSYHLFFSHHKRTHS HHHHHHHCCCCCCCC	19.83	26074081
296	Phosphorylation	TLHQRIHTGEKPYEC EEEEEECCCCCCCCH	44.67	29496963
304	Sumoylation	GEKPYECKECGKAFR CCCCCCHHHHHHHHH	44.06	-
304	Sumoylation	GEKPYECKECGKAFR CCCCCCHHHHHHHHH	44.06	-
324	Phosphorylation	TQHQRLHTGEKPYEC HHHHHCCCCCCCCCC	52.18	26055452
327	Ubiquitination	QRLHTGEKPYECKQC HHCCCCCCCCCCCHH	55.00	-
327	Sumoylation	QRLHTGEKPYECKQC HHCCCCCCCCCCCHH	55.00	-
327	Sumoylation	QRLHTGEKPYECKQC HHCCCCCCCCCCCHH	55.00	-
332	Sumoylation	GEKPYECKQCGKAFI CCCCCCCCHHCCHHH	36.36	-
332	Sumoylation	GEKPYECKQCGKAFI CCCCCCCCHHCCHHH	36.36	-
345	Phosphorylation	FIRGFQLTEHLRLHT HHHHHCCHHHEEECC	15.58	24719451
352	Phosphorylation	TEHLRLHTGEKPYEC HHHEEECCCCCCEEC	52.18	23312004
355	Ubiquitination	LRLHTGEKPYECKEC EEECCCCCCEECCCC	55.00	-
355	Sumoylation	LRLHTGEKPYECKEC EEECCCCCCEECCCC	55.00	-
355	Sumoylation	LRLHTGEKPYECKEC EEECCCCCCEECCCC	55.00	-
360	Ubiquitination	GEKPYECKECGKTFR CCCCEECCCCCCEEE	44.06	-
360	Sumoylation	GEKPYECKECGKTFR CCCCEECCCCCCEEE	44.06	-
360	Sumoylation	GEKPYECKECGKTFR CCCCEECCCCCCEEE	44.06	-
380	Phosphorylation	TIHQRIHTGEKPYEC EEEEECCCCCCCEEH	44.67	28111955
436	Phosphorylation	TLHQRIHTGEKPYEC EEEECCCCCCCCCCH	44.67	29496963
444	Sumoylation	GEKPYECKECGKTFR CCCCCCHHHHCCHHH	44.06	-
444	Sumoylation	GEKPYECKECGKTFR CCCCCCHHHHCCHHH	44.06	-
444	Ubiquitination	GEKPYECKECGKTFR CCCCCCHHHHCCHHH	44.06	-
492	Phosphorylation	IQHQRIHTGEKPYEC HHCCCCCCCCCCCCC	44.67	29496963
500	Sumoylation	GEKPYECKECGKAFS CCCCCCCCCCCCEEE	44.06	-
500	Sumoylation	GEKPYECKECGKAFS CCCCCCCCCCCCEEE	44.06	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN461_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN461_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN461_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SF01_HUMAN	SF1	physical	16595694
HDAC2_HUMAN	HDAC2	physical	16595694
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.