ZMYM5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZMYM5_HUMAN
• UniProt AC: Q9UJ78
• Protein Name: Zinc finger MYM-type protein 5
• Gene Name: ZMYM5
• Organism: Homo sapiens (Human).
• Sequence Length: 669
• Subcellular Localization: Nucleus .
• Protein Description: Functions as a transcriptional regulator..
• Protein Sequence: MEKCSVGGLELTEQTPALLGNMAMATSLMDIGDSFGHPACPLVSRSRNSPVEDDDDDDDVVFIESIQPPSISAPAIADQRNFIFASSKNEKPQGNYSVIPPSSRDLASQKGNISETIVIDDEEDIETNGGAEKKSSCFIEWGLPGTKNKTNDLDFSTSSLSRSKTKTGVRPFNPGRMNVAGDLFQNGEFATHHSPDSWISQSASFPSNQKQPGVDSLSPVALLRKQNFQPTAQQQLTKPAKITCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKRTQNTRSIICKKDASTKKANVILPVESSKSFQEFYSTSCLSPCENNWNLKKGVFNKSRCTICSKLAEIRHEVSVNNVTHKLCSNHCFNKYRLANGLIMNCCEHCGEYMPSKSTGNNILVIGGQQKRFCCQSCINEYKQMMETKSKKLTASENRKRNAFREENEKQLYGSSNTLLKKIEGIPEKKEKTSQLQLSVECGTDTLLIQENVNLPPSSTSTIADTFQEQLEEKNFEDSIVPVVLSADPGTWPRILNIKQRDTLVENVPPQVRNFNFPKDNTGRKFSETYYTRILPNGEKTTRSWLLYSTSKDSVFCLYCKLFGEGKNQLKNENGCKDWQHLSHILSKHEESEMHVNNSVKYSKLKSDLKKNKAIDAAEHRLYENEKNDGVLLLYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEKCSVGGLELT ---CCCCCCCCEECC	34.56	22210691
12	Phosphorylation	SVGGLELTEQTPALL CCCCEECCCCCHHHH	19.37	22210691
15	Phosphorylation	GLELTEQTPALLGNM CEECCCCCHHHHHHH	12.33	22210691
46	Phosphorylation	ACPLVSRSRNSPVED CCCCCCCCCCCCCCC	28.45	27080861
49	Phosphorylation	LVSRSRNSPVEDDDD CCCCCCCCCCCCCCC	29.25	27251275
88	Sumoylation	NFIFASSKNEKPQGN CEEEEECCCCCCCCC	67.63	-
88	Sumoylation	NFIFASSKNEKPQGN CEEEEECCCCCCCCC	67.63	28112733
91	Sumoylation	FASSKNEKPQGNYSV EEECCCCCCCCCCCC	52.62	28112733
114	Phosphorylation	ASQKGNISETIVIDD HHCCCCCCCEEEECC	32.46	22210691
127	Phosphorylation	DDEEDIETNGGAEKK CCHHHHCCCCCCCCC	39.23	22210691
134	Sumoylation	TNGGAEKKSSCFIEW CCCCCCCCCCEEEEE	38.82	-
134	Sumoylation	TNGGAEKKSSCFIEW CCCCCCCCCCEEEEE	38.82	28112733
149	Sumoylation	GLPGTKNKTNDLDFS CCCCCCCCCCCCCCC	50.70	28112733
149	Ubiquitination	GLPGTKNKTNDLDFS CCCCCCCCCCCCCCC	50.70	29967540
149	Sumoylation	GLPGTKNKTNDLDFS CCCCCCCCCCCCCCC	50.70	-
150	Phosphorylation	LPGTKNKTNDLDFST CCCCCCCCCCCCCCH	43.27	-
156	Phosphorylation	KTNDLDFSTSSLSRS CCCCCCCCHHHHCCC	27.35	27174698
157	Phosphorylation	TNDLDFSTSSLSRSK CCCCCCCHHHHCCCC	23.48	27174698
158	Phosphorylation	NDLDFSTSSLSRSKT CCCCCCHHHHCCCCC	28.25	27174698
159	Phosphorylation	DLDFSTSSLSRSKTK CCCCCHHHHCCCCCC	30.38	27174698
161	Phosphorylation	DFSTSSLSRSKTKTG CCCHHHHCCCCCCCC	36.13	27174698
163	Phosphorylation	STSSLSRSKTKTGVR CHHHHCCCCCCCCCC	41.10	27174698
165	Phosphorylation	SSLSRSKTKTGVRPF HHHCCCCCCCCCCCC	34.78	-
166	Sumoylation	SLSRSKTKTGVRPFN HHCCCCCCCCCCCCC	47.20	-
166	Sumoylation	SLSRSKTKTGVRPFN HHCCCCCCCCCCCCC	47.20	28112733
202	Phosphorylation	PDSWISQSASFPSNQ CCCHHHCCCCCCCCC	21.06	22210691
204	Phosphorylation	SWISQSASFPSNQKQ CHHHCCCCCCCCCCC	42.83	22210691
207	Phosphorylation	SQSASFPSNQKQPGV HCCCCCCCCCCCCCC	50.29	22210691
216	Phosphorylation	QKQPGVDSLSPVALL CCCCCCCCCCHHHHH	28.48	29255136
218	Phosphorylation	QPGVDSLSPVALLRK CCCCCCCCHHHHHHH	22.68	29255136
225	Sumoylation	SPVALLRKQNFQPTA CHHHHHHHCCCCCCH	49.95	28112733
253	Ubiquitination	NCKKPLQKGQTAYQR CCCCCCCCCCCHHHC	61.75	32015554
256	Phosphorylation	KPLQKGQTAYQRKGS CCCCCCCCHHHCCCC	35.68	-
275	Phosphorylation	CSTTCLSSFSHKRTQ EECHHHHHCCCCCCC	20.16	15302935
294	Phosphorylation	IICKKDASTKKANVI EEEECCCCCCCCEEE	51.39	-
297	Sumoylation	KKDASTKKANVILPV ECCCCCCCCEEEEEE	45.33	-
391	Phosphorylation	GEYMPSKSTGNNILV HCCCCCCCCCCCEEE	45.98	-
392	Phosphorylation	EYMPSKSTGNNILVI CCCCCCCCCCCEEEE	47.90	-
410	Phosphorylation	QKRFCCQSCINEYKQ CCEEEHHHHHHHHHH	11.75	23879269
415	Phosphorylation	CQSCINEYKQMMETK HHHHHHHHHHHHHHH	11.30	23879269
421	Phosphorylation	EYKQMMETKSKKLTA HHHHHHHHHHHHCCC	23.79	24702127
422	Sumoylation	YKQMMETKSKKLTAS HHHHHHHHHHHCCCC	47.15	-
423	Phosphorylation	KQMMETKSKKLTASE HHHHHHHHHHCCCCH	42.30	24702127
443	Ubiquitination	AFREENEKQLYGSSN HHHHHHHHHHHCCHH	58.13	29967540
443	Sumoylation	AFREENEKQLYGSSN HHHHHHHHHHHCCHH	58.13	28112733
455	Sumoylation	SSNTLLKKIEGIPEK CHHHHHHHHCCCCCH	46.06	-
455	Sumoylation	SSNTLLKKIEGIPEK CHHHHHHHHCCCCCH	46.06	28112733
462	Sumoylation	KIEGIPEKKEKTSQL HHCCCCCHHCCCCCC	61.96	28112733
532	Ubiquitination	WPRILNIKQRDTLVE HHHHCCCCCCCCCHH	37.90	-
552	Sumoylation	VRNFNFPKDNTGRKF CCCCCCCCCCCCCCC	60.52	28112733
558	Ubiquitination	PKDNTGRKFSETYYT CCCCCCCCCCEEEEE	55.37	29967540
558	Sumoylation	PKDNTGRKFSETYYT CCCCCCCCCCEEEEE	55.37	-
560	Phosphorylation	DNTGRKFSETYYTRI CCCCCCCCEEEEEEE	31.87	28450419
616	Phosphorylation	CKDWQHLSHILSKHE CCCHHHHHHHHHHCC	13.32	-
632	Phosphorylation	SEMHVNNSVKYSKLK HHHHCCCCHHHHHHH	18.12	-
668	Phosphorylation	NDGVLLLYT------ CCCEEEEEC------	15.46	24719451
669	Phosphorylation	DGVLLLYT------- CCEEEEEC-------	31.91	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZMYM5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZMYM5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZMYM5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
ANM1_HUMAN	PRMT1	physical	23455924
ACD11_HUMAN	ACAD11	physical	26186194
KS6A2_HUMAN	RPS6KA2	physical	26186194
KS6A3_HUMAN	RPS6KA3	physical	26186194
KS6A3_HUMAN	RPS6KA3	physical	28514442
KS6A2_HUMAN	RPS6KA2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.