ZFP42_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZFP42_HUMAN
• UniProt AC: Q96MM3
• Protein Name: Zinc finger protein 42 homolog
• Gene Name: ZFP42
• Organism: Homo sapiens (Human).
• Sequence Length: 310
• Subcellular Localization: Nucleus.
• Protein Description: Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity)..
• Protein Sequence: MSQQLKKRAKTRHQKGLGGRAPSGAKPRQGKSSQDLQAEIEPVSAVWALCDGYVCYEPGPQALGGDDFSDCYIECVIRGEFSQPILEEDSLFESLEYLKKGSEQQLSQKVFEASSLECSLEYMKKGVKKELPQKIVGENSLEYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARKKPPINKEYDSLSAIACPQSGCTRKLRNRAALRKHLLIHGPRDHVCAECGKAFVESSKLKRHFLVHTGEKPFRCTFEGCGKRFSLDFNLRTHVRIHTGEKRFVCPFQGCNRRFIQSNNLKAHILTHANTNKNEQEGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Ubiquitination	FESLEYLKKGSEQQL HHHHHHHHHCCHHHH	54.94	23503661
100	Ubiquitination	ESLEYLKKGSEQQLS HHHHHHHHCCHHHHH	66.14	23503661
114	Phosphorylation	SQKVFEASSLECSLE HHHHHHHHHHHHHHH	28.40	20068231
115	Phosphorylation	QKVFEASSLECSLEY HHHHHHHHHHHHHHH	34.92	20068231
119	Phosphorylation	EASSLECSLEYMKKG HHHHHHHHHHHHHHC	18.17	20068231
122	Phosphorylation	SLECSLEYMKKGVKK HHHHHHHHHHHCCHH	21.37	20068231
129	Ubiquitination	YMKKGVKKELPQKIV HHHHCCHHHCCHHHC	63.18	22817900
134	Ubiquitination	VKKELPQKIVGENSL CHHHCCHHHCCCCCC	37.10	22817900
150	Ubiquitination	YSEYMTGKKLPPGGI HHHHHCCCCCCCCCC	41.81	21906983
151	Ubiquitination	SEYMTGKKLPPGGIP HHHHCCCCCCCCCCC	68.52	22817900
166	Ubiquitination	GIDLSDPKQLAEFAR CCCCCCHHHHHHHHH	64.03	22817900
182	Phosphorylation	KPPINKEYDSLSAIA CCCCCCCCCCCHHEE	16.67	18452278
196	Phosphorylation	ACPQSGCTRKLRNRA ECCCCCCCHHHHHHH	34.07	-
224	Ubiquitination	HVCAECGKAFVESSK HHHHHHHHHHHHHHH	50.76	22817900
229	Phosphorylation	CGKAFVESSKLKRHF HHHHHHHHHHHCEEE	27.72	29214152
231	Sumoylation	KAFVESSKLKRHFLV HHHHHHHHHCEEEEE	68.27	-
231	Ubiquitination	KAFVESSKLKRHFLV HHHHHHHHHCEEEEE	68.27	-
231	Sumoylation	KAFVESSKLKRHFLV HHHHHHHHHCEEEEE	68.27	-
231	Acetylation	KAFVESSKLKRHFLV HHHHHHHHHCEEEEE	68.27	30593531
240	Phosphorylation	KRHFLVHTGEKPFRC CEEEEEECCCCCEEE	39.29	-
257	Phosphorylation	EGCGKRFSLDFNLRT ECCCCEEEEEEECCE	30.94	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RLIM	Q9NVW2	PMID:22596162

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZFP42_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZFP42_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YAF2_HUMAN	YAF2	physical	21530438
EED_HUMAN	EED	physical	21530438
RYBP_HUMAN	RYBP	physical	21530438
RING1_HUMAN	RING1	physical	21530438
RING2_HUMAN	RNF2	physical	21530438

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.