| UniProt ID | WNT9B_HUMAN | |
|---|---|---|
| UniProt AC | O14905 | |
| Protein Name | Protein Wnt-9b | |
| Gene Name | WNT9B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 357 | |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix . Secreted . | |
| Protein Description | Ligand for members of the frizzled family of seven transmembrane receptors. [PubMed: 20093360 Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity] | |
| Protein Sequence | MRPPPALALAGLCLLALPAAAASYFGLTGREVLTPFPGLGTAAAPAQGGAHLKQCDLLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPGTAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCKH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | O-linked_Glycosylation | TPFPGLGTAAAPAQG CCCCCCCCCCCCCCC | 20.40 | OGP | |
| 99 | N-linked_Glycosylation | QFRHERWNCSLEGRM HCCCCHHCCCHHHCH | 16.24 | UniProtKB CARBOHYD | |
| 174 | Phosphorylation | KYSTKFLSNFLGSKR HHHHHHHHHHHCCCC | 28.77 | - | |
| 184 | Methylation | LGSKRGNKDLRARAD HCCCCCCHHHHHHHH | 62.05 | - | |
| 216 | O-palmitoleoylation | TCKCHGVSGSCAVRT EEECCCCCCCCHHHH | 29.58 | - | |
| 229 | Phosphorylation | RTCWKQLSPFRETGQ HHHHHHCCCCHHHCC | 21.35 | 24719451 | |
| 234 | Phosphorylation | QLSPFRETGQVLKLR HCCCCHHHCCEEEEE | 28.76 | 27251275 | |
| 306 | Phosphorylation | GTAGRVCSREASCSS CCCCCCCCCCCCCCH | 30.23 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WNT9B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WNT9B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WNT9B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GRP78_HUMAN | HSPA5 | physical | 26186194 | |
| ZZEF1_HUMAN | ZZEF1 | physical | 26186194 | |
| NDUA2_HUMAN | NDUFA2 | physical | 26186194 | |
| HECD3_HUMAN | HECTD3 | physical | 26186194 | |
| ZZEF1_HUMAN | ZZEF1 | physical | 28514442 | |
| HECD3_HUMAN | HECTD3 | physical | 28514442 | |
| NDUA2_HUMAN | NDUFA2 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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