WN10B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WN10B_HUMAN
• UniProt AC: O00744
• Protein Name: Protein Wnt-10b
• Gene Name: WNT10B
• Organism: Homo sapiens (Human).
• Sequence Length: 389
• Subcellular Localization: Secreted, extracellular space, extracellular matrix . Secreted .
• Protein Description: Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin..
• Protein Sequence: MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	PRPRPPPSGLAGLLF CCCCCCCCHHHHHHH	52.81	24043423
24	Phosphorylation	LLFLALCSRALSNEI HHHHHHHHHHHHCCC	22.80	24043423
46	Phosphorylation	EPPLTANTVCLTLSG CCCCCHHHEEEECCC	15.33	18669648
50	Phosphorylation	TANTVCLTLSGLSKR CHHHEEEECCCCCHH	17.47	18669648
52	Phosphorylation	NTVCLTLSGLSKRQL HHEEEECCCCCHHHH	32.24	18669648
93	N-linked_Glycosylation	QLRDQRWNCSALEGG HHHHCCCCCCCCCCC	16.44	UniProtKB CARBOHYD
253	O-palmitoleoylation	KCKCHGTSGSCQFKT HCCCCCCCCCCCCCC	33.05	-
335	N-linked_Glycosylation	GTRGRACNKTSRLLD CHHHCCCCCHHHHCC	50.05	UniProtKB CARBOHYD
364	S-palmitoylation	RQTRVERCHCRFHWC HHHCHHHCCCCEEHH	1.94	29575903
366	S-palmitoylation	TRVERCHCRFHWCCY HCHHHCCCCEEHHHH	5.94	29575903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WN10B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WN10B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WN10B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
2ABD_HUMAN	PPP2R2D	physical	26186194
PP6R2_HUMAN	PPP6R2	physical	26186194
FSTL1_HUMAN	FSTL1	physical	26186194
CO6A2_HUMAN	COL6A2	physical	26186194
JMJD8_HUMAN	JMJD8	physical	26186194
JMJD8_HUMAN	JMJD8	physical	28514442
2ABD_HUMAN	PPP2R2D	physical	28514442
FSTL1_HUMAN	FSTL1	physical	28514442
CO6A2_HUMAN	COL6A2	physical	28514442
LRP6_HUMAN	LRP6	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 225300: Split-hand/foot malformation 6 (SHFM6)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-46; THR-50 AND SER-52,AND MASS SPECTROMETRY.
PubMed: 18669648