WAK1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WAK1_ARATH
• UniProt AC: Q39191
• Protein Name: Wall-associated receptor kinase 1
• Gene Name: WAK1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 735
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development. Required during plant's response to pathogen infection and in plant defense against heavy metal toxicity. Phosphorylates the oxygen-evolving enhancer protein 2 (OEE2) in an GRP-3-dependent manner..
• Protein Sequence: MKVQEGLFLVAIFFSLACTQLVKGQHQPGENCQNKCGNITIEYPFGISSGCYYPGNESFSITCKEDRPHVLSDIEVANFNHSGQLQVLLNRSSTCYDEQGKKTEEDSSFTLENLSLSANNKLTAVGCNALSLLDTFGMQNYSTACLSLCDSPPEADGECNGRGCCRVDVSAPLDSYTFETTSGRIKHMTSFHDFSPCTYAFLVEDDKFNFSSTEDLLNLRNVMRFPVLLDWSVGNQTCEQVGSTSICGGNSTCLDSTPRNGYICRCNEGFDGNPYLSAGCQDVNECTTSSTIHRHNCSDPKTCRNKVGGFYCKCQSGYRLDTTTMSCKRKEFAWTTILLVTTIGFLVILLGVACIQQRMKHLKDTKLREQFFEQNGGGMLTQRLSGAGPSNVDVKIFTEDGMKKATNGYAESRILGQGGQGTVYKGILPDNSIVAIKKARLGDSSQVEQFINEVLVLSQINHRNVVKLLGCCLETEVPLLVYEFITNGTLFDHLHGSMIDSSLTWEHRLKIAIEVAGTLAYLHSSASIPIIHRDIKTANILLDVNLTAKVADFGASRLIPMDKEELETMVQGTLGYLDPEYYNTGLLNEKSDVYSFGVVLMELLSGQKALCFKRPQSSKHLVSYFATATKENRLDEIIGGEVMNEDNLKEIQEAARIAAECTRLMGEERPRMKEVAAKLEALRVEKTKHKWSDQYPEENEHLIGGHILSAQGETSSSIGYDSIKNVAILDIETGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	N-linked_Glycosylation	NCQNKCGNITIEYPF CCCCCCCCEEEEECC	37.39	-
56	N-linked_Glycosylation	SGCYYPGNESFSITC CCCCCCCCCCEEEEE	36.92	-
80	N-linked_Glycosylation	DIEVANFNHSGQLQV EEEEEECCCCCCEEE	28.37	-
90	N-linked_Glycosylation	GQLQVLLNRSSTCYD CCEEEEECCCCCCCC	37.31	-
113	N-linked_Glycosylation	DSSFTLENLSLSANN CCCEEEEEEEECCCC	37.73	-
140	N-linked_Glycosylation	LDTFGMQNYSTACLS HHHHCCCCCCCHHHH	24.67	-
209	N-linked_Glycosylation	LVEDDKFNFSSTEDL EECCCCCCCCCHHHH	41.45	-
235	N-linked_Glycosylation	LLDWSVGNQTCEQVG EEECCCCCCEECEEC	31.65	-
250	N-linked_Glycosylation	STSICGGNSTCLDST CCEECCCCCCCCCCC	21.30	-
296	N-linked_Glycosylation	SSTIHRHNCSDPKTC CCCHHCCCCCCCHHH	27.26	-
385	Phosphorylation	GMLTQRLSGAGPSNV CCEEECCCCCCCCCC	28.87	25561503
398	Phosphorylation	NVDVKIFTEDGMKKA CCEEEEECCCHHHHH	36.32	-
482	Phosphorylation	TEVPLLVYEFITNGT CCCCEEEEEHHHCCC	12.70	-
568	Phosphorylation	MDKEELETMVQGTLG CCHHHHHHHHHHHHH	34.95	-
573	Phosphorylation	LETMVQGTLGYLDPE HHHHHHHHHHCCCHH	10.42	-
581	Phosphorylation	LGYLDPEYYNTGLLN HHCCCHHHHCCCCCC	13.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WAK1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WAK1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WAK1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSBP1_ARATH	PSBP-1	physical	12767910
GRP3_ARATH	GRP-3	physical	11335717
P2C70_ARATH	KAPP	physical	11335717

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.