VPS26_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS26_DROME
• UniProt AC: Q9W552
• Protein Name: Vacuolar protein sorting-associated protein 26
• Gene Name: Vps26
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 478
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein .
• Protein Description: Component of the retromer complex which acts in conjunction with wingless (wg) and clathrin-mediated endocytosis to sustain a wntless (wls) traffic loop. This loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, thereby enabling wls to direct wg secretion. The hh and dpp signaling pathways do not require the retromer complex suggesting that it does not play a general role in exocytosis..
• Protein Sequence: MNFLGFGQSADIEIVFDGAEHKTAEVKGEDGKVEKMLLFYDGETVSGKVNVTLKKPGSKLEHQGIKIEFIGQIELYYDRGNHHEFKCLAKALARPGDLIQNNSYPFDFPKVEKQFEVYAGSNVRLRYFLRATIVRRISDITKEVDIAVHTLCSYPEMNNPIKMEVGIEDCLHIEFEYNKSKYHLRDTIIGKIYFLLVRIKIKHMEIAIIKKESTGTGPTMFNENETIAKYEIMDGAPVKGESIPIRVFLAGYNLTPTMRDINKKFSVKYFLNLVLMDTEDRRYFKQQEITLWRKADKPRYHGAQQHQQQQHQHVPLHAPPHLVSGPAAPTVAHSLISSSTDSGEVGGAPTAPGTAGSESKMGLFTRESPNQEFSQQQMDSPPLTPTPSTASVAVAVPTAASSVSEPAPERGIGDGAAAATTSASPVAMLSSSPPPLLPVSPLSRSETEASEQVQPEDEDLDAITPNTKKTGATPLATD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Ubiquitination	SYPFDFPKVEKQFEV CCCCCCCCCEEEEEE	64.12	31113955
365	Phosphorylation	ESKMGLFTRESPNQE CCCCCEEECCCCCHH	38.27	22668510
368	Phosphorylation	MGLFTRESPNQEFSQ CCEEECCCCCHHHHH	26.34	22668510
380	Phosphorylation	FSQQQMDSPPLTPTP HHHHHCCCCCCCCCC	24.07	21082442
384	Phosphorylation	QMDSPPLTPTPSTAS HCCCCCCCCCCCCCE	30.78	22668510
422	Phosphorylation	GAAAATTSASPVAML CCCCCCCCCCCCHHH	23.53	19429919
424	Phosphorylation	AAATTSASPVAMLSS CCCCCCCCCCHHHCC	21.48	19429919
430	Phosphorylation	ASPVAMLSSSPPPLL CCCCHHHCCCCCCCC	18.71	19429919
431	Phosphorylation	SPVAMLSSSPPPLLP CCCHHHCCCCCCCCC	42.79	19429919
432	Phosphorylation	PVAMLSSSPPPLLPV CCHHHCCCCCCCCCC	37.74	19429919
440	Phosphorylation	PPPLLPVSPLSRSET CCCCCCCCCCCCCCC	20.41	30478224
445	Phosphorylation	PVSPLSRSETEASEQ CCCCCCCCCCCHHHC	45.56	19429919
447	Phosphorylation	SPLSRSETEASEQVQ CCCCCCCCCHHHCCC	37.79	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS26_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS26_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS26_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OPS1_DROME	ninaE	genetic	24781186
DYN_DROME	shi	genetic	24781186

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.